Liposome Formulation for Cosmetics Industry

Liposomes, with a structure similar to cell membranes, can facilitate the penetration of active ingredients into the skin and enhance their entry into the stratum corneum or epidermal lipids. This leads to increased accumulation of active ingredients in local skin, thereby improving bioavailability, reducing adverse reactions, and providing a sustained-release effect. At CD Formulation, our focus lies in exploring the utilization of liposome technology within the realm of cosmetics.

Transdermal Mechanisms of Liposomes

Nanocosmetics operate through a variety of delivery mechanisms, with the following mechanisms serving as typical examples.

• Penetration mechanism. Complete liposomes can pass through the stratum corneum and even penetrate deep into the skin, reaching blood vessels.
• Hydration mechanism. Liposomes can hydrate the stratum corneum, enhance the water-binding capacity, widen the intercellular spaces of the stratum corneum, disrupt the arrangement of the hydrophobic tails in the lipid bilayer, and ultimately allow the lipophilic drugs to enter the intercellular spaces through diffusion and capillary suction.
• Fusion mechanism. The phospholipids in liposomes are "similarly soluble" with the lipids in the stratum corneum, which causes changes in the lipid composition and structure of the stratum corneum, forming a flat granular structure. The effective components encapsulated by liposomes can enter the skin through the gaps of the lipid particles.

Fig.1 Mechanism of liposome transdermal absorption. (Abdalla, Ahmed, et al, 2024)

Advantages of Liposomes in Cosmetics

• Protective Function and Low Stimulation. Enhancing the stability of active ingredients both internally and externally, thereby reducing skin irritation.
• Amphipathic Property. Capable of transporting water-soluble and lipid-soluble active substances to the deeper layers of the skin.
• Sustained Release. Enabling a gradual release of active ingredients, prolonging their effectiveness on the skin.
• Improved Osmotic Permeability. The skin transdermal absorption efficiency is significantly improved, leading to targeted delivery of active ingredients into the dermis layer and thereby enhancing their bioavailability.
• Moisturizing Function. Maintaining skin moisture, while lipids penetrate deep into the skin can inhibit water diffusion within the skin, thus moisturizing and softening it.
• Skin Care Function. Reducing excess fat and toxin deposition on the skin, moisturizing keratinized tissue, and promoting overall skincare.
• Enhanced Skin Texture. The skin now feels smoother and more conducive to healthy skin.
• Solubility in Water. With 100% solubility in water, the introduction of this substance into water leads to the Tyndall effect, effectively addressing the application limitations associated with water-insoluble active substances.

Main Applications of Liposomes in Cosmetic Industry

Liposomes can function as both a carrier for cosmetic ingredients and an active agent. In cases of eczema or skin damage caused by moisture loss, hollow liposomes can effectively interact with the skin's lipids, proteins, and carbohydrates, facilitating the restoration of normal skin conditions and enabling the stratum corneum to resume its defensive role. Our liposomes stand out from conventional liposomes due to their possession of nearly all the essential traits necessary for cosmetics development and production. 

Applications	Case Studies
Raw Material of Cosmetics	The ability to encapsulate numerous active ingredients through liposome technology includes but is not limited to: Ceramide Retinol Q10 coenzyme Q10 Astaxanthin SOD Resveratrol Salicylic acid Asiaticoside Meadowfoam seed oil Jojoba Seed Oil
Serum	Case 1-Long-lasting vitamin C and E Serum. Effectiveness: Moisturization & Skin whitening Specifics: These products offer powerful antioxidant effects through sustained release microcapsule technology, allowing for deep penetration into the skin to deliver ingredients that stimulate collagen synthesis and provide potent antioxidants where they are most needed. The formulation contains lipid-soluble vitamin C, vitamin E, and phospholipid essential fatty acids, resulting in firmer, more moisturized, and elastic skin.
Cosmetic Lotion	Case 2-Natural Moisturizing & Anti-wrinkle Lotion Active Ingredients: soluble collagen, elastin, laminin Human Efficacy Evaluation The skin's firmness increased by 41.5%+ after 28 days of using the lotion.
Facial Cream & Eye Cream	Case 3-Anti-wrinkle & Skin Whitening Cream Active Ingredients. Hydrolyzed collagen, Aspergillus fermentation product, palmitoyl tripeptide-1, palmitoyl tripeptide-8, and sodium hyaluronate Human Efficacy Evaluation
Hair Care Products	Case 4-Hair Growth Liposomal Item Form: Liquid Main Ingredients: Vitamin E, B6, pantothenic acid About this product This super absorbent liposome nourishes your hair and skin from the inside out!
Makeup Products	Case 5- Advanced Foundation Booster formulated with Liposomes Active Ingredient: Non-acidic Vitamin C, Coenzyme Q10, Aloe Vera, Lavender Water Extract, and Hyaluronic Acid are included in the formula. About this product This smooth, matte foundation is infused with the rejuvenating properties of glacial water, delivering a silky veil to the skin while subtly reducing visible signs of aging. It serves not only as a base, but also as a pigmented essence.

Explore Our Liposome Formulation Services for Cosmetics Industry

As a pioneer in liposome technology, CD Formulation specializes in applying liposome technology to raw materials for the cosmetics and dermatological pharmaceutical industries, as well as in the development and production of various products. Please feel free to contact us if you need any assistance.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.