Proteins & Peptides Hydrogels Delivery System Development

Hydrogels have emerged as potential drug delivery carriers for peptides and proteins, which can protect protein/peptide bioactive molecules from degradation and release them from the hydrogel matrix in a controlled manner over a long period of time. As a solution provider for the development of innovative protein/peptide delivery systems, CD Formulation has established a versatile macromolecular hydrogel delivery platform that can be designed and developed for the delivery of different types of protein and peptide drugs.

Potential Advantages of Hydrogel Delivery of Protein/Peptide

Hydrogel is a three-dimensional hydrophilic polymer network composed of cross-linked water-soluble polymer chains, which can absorb a large amount of water but are insoluble in water and biological fluids.

Hydrogel-based drug carriers are an emerging protein/peptide delivery system. The hydrogel delivery system uses non-toxic, biocompatible, and biodegradable water-soluble polymers as carriers or media to chemically or physically combine with proteins/peptides to form corresponding drug dosage forms. The hydrogel delivery system enters the body through chemical diffusion or penetration, and releases proteins/peptides slowly and continuously into the human body at a stable rate and appropriate concentration, thereby improving the efficacy of the drug, reducing the dosage of the drug, and achieving the best therapeutic effect. Different polymer-carriers, as one of the important components of the hydrogel system, have different delivery characteristics and sustained-release properties for proteins/peptides. Hydrogels can be made of polymers of various shapes and forms and are designed to respond to various physiological stimuli, enabling the controlled and targeted release of encapsulated peptides and proteins over a long period.

Fig. 1 Protein/peptide therapeutic (orange spheres) encapsulated in a hydrogel. (CD Formulation)

Explore Our Proteins & Peptides Hydrogels Delivery System Development Services

As an expert in protein/peptide science and formulation science, CD Formulation has the most advanced industry knowledge and technology in protein and peptide delivery and is committed to providing you with comprehensive, innovative, and systematic hydrogel delivery system development solutions.

Our experienced team of scientists is good at using a variety of hydrogel materials, such as chitosan, alginate, and N-isopropyl acrylamide (NIPAM) to customize and develop powerful innovative hydrogel delivery systems for you to meet your specific needs.

Available hydrogel materials include:

• Natural polymer materials: chitosan, alginate, cyclodextrin, and collagen...
• Synthetic polymer materials: such as N-isopropyl acrylamide (NIPAM), acrylamide, polyvinyl alcohol (PVA), and polyethylene glycol (PEG).

Thanks to years of continuous exploration of hydrogel systems, we have established an advanced and systematic hydrogel platform that can design and develop protein/peptide hydrogel delivery systems with different properties, including:

Depending on the clinical application and disease area, these hydrogel delivery systems are designed by our scientists to enter the body in different ways, including:

• Injectable
• Buccal
• Oral
• Transdermal
• Vaginal
• Ocular
• Wound Dressing
• Implant

Fig. 2 Administration routes of hydrogel protein/peptide delivery systems. (CD Formulation)

Our Hydrogel Preparation Methods

In order to make the hydrogel have certain biodegradability and sufficient strength, our team of formulation scientists uses various types of physical and chemical methods to crosslink the hydrogel, including:

• Physical methods: including radiation, ultraviolet irradiation, etc.
• Chemical methods: including suspension polymerization, step-growth polymerization, grafting, hydrophobic interaction, ionic interaction, hydrogen bonding, etc.

Fig. 3 Chemical and physical crosslinking of hydrogels. (Lei L, et al., 2022)

Our Hydrogel Characterization Technology

• Spectral analysis: Our scientists use Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (NMR) to detect the chemical composition of the hydrogel, and determine whether the hydrogel is successfully cross-linked by observing the changes in the absorption peaks of the chemical groups and the movement of the characteristic peaks.
• Scanning electron microscopy (SEM): It is used to detect the surface morphology and internal fine structure of the hydrogel.
• Swelling test: It is used to test the absorption or release ability of the hydrogel material as a sustained-release drug carrier matrix.
• Differential scanning calorimetry (DSC): It is used to characterize the hydrogel material's phase transition temperature and the polymer's effect on the phase transition temperature.

Why Choose Us for Proteins & Peptides Hydrogels Delivery System Development?

• Extensive expertise and experience in performing protein/peptide hydrogel delivery system development.
• Successful experience in hundreds of hydrogel delivery systems.
• We have a flexible team of experts responsible for hydrogel formulation feasibility, process development, and commercial manufacturing.
• We provide comprehensive hydrogel delivery system characterization services using a range of analytical techniques, including Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), scanning electron microscopy (SEM), etc.
• Scalable hydrogel manufacturing processes and capabilities.
• We provide flexible and tailored solutions to meet our customers' specific needs and requirements.
• Fast and efficient services ensure that our customers' projects are delivered on time.

Publication

CD Formulation is continually researching and developing new technologies to improve protein/peptide hydrogel delivery systems. Our scientists stay up to date on the latest advances in the field to provide you with innovative solutions that can enhance protein and peptide delivery. Please don't hesitate to contact us if you are interested in our services.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.