Proteins & Peptides Oral Delivery System Development

Oral administration, as an ideal drug delivery method, has become a hot topic in the research of protein and peptide drug delivery systems. CD Formulation masters cutting-edge technology and expertise in the development of therapeutic protein and peptide formulations and oral drug delivery systems, and is committed to providing innovative solutions for improving the oral bioavailability and stability of protein and peptide drugs.

Challenges for Oral Delivery of Protein/Peptide

Proteins and peptides have gradually become attractive therapeutic molecules due to their high selectivity, good efficacy, and few side effects. However, most protein and peptide drugs are large molecule hydrophilic drugs, which are easily degraded by gastric acid and pepsin under the extreme environment of gastrointestinal stability. At the same time, due to their hydrophilicity, they cannot effectively penetrate physiological barriers such as tight junctions between cells such as the small intestinal mucosa and epithelial layer. This makes the development of oral delivery systems for proteins and peptides face many challenges. It is necessary to fully combine and utilize strategies such as nanotechnology and enteric coating to avoid enzymatic degradation in the digestive system and improve the oral bioavailability of drugs.

Fig. 1 Major barriers to oral delivery of peptide and protein-based drugs.(Cao SJ, et al., 2019)

Explore Our Proteins & Peptides Oral Delivery System Development Services

CD Formulation is an expert in therapeutic protein/peptide science and formulation science, focusing on combining advanced formulation technology with protein/peptide knowledge to develop first-class protein/peptide oral delivery systems. Our scientists deploy a range of strategies, chemical modification, the addition of effective agents, nano-carrier systems, and medical devices to improve the bioavailability and stability of these challenging molecules.

Importantly, our team of scientists has extensive formulation development experience and expertise to design formulations suitable for different protein/peptide compounds, such as spray-dried formulations, lyophilized formulations, tablets, capsules, etc., to support the development of oral delivery systems.

Fig. 2 Our formulation strategies for oral delivery of protein/peptide. (CD Formulation)

• Our services include but are not limited to:
• Protein/peptide formulation development and optimization.
• Protein and peptide stability studies and evaluations.
• Oral drug delivery system formulation optimization.
• In vitro and in vivo evaluation of oral drug delivery systems.
• Process development and optimization.
• Process transfer.

Our Solutions for Proteins & Peptides Oral Delivery System Development

The successful development of protein/peptide oral delivery systems lies in protecting these unstable active pharmaceutical ingredients to ensure that they can remain stable in gastric acid and other digestive juices.

1) At CD Formulation, an effective strategy is to stably encapsulate proteins/peptides in nanocarriers. This usually involves selecting suitable carrier materials, such as polymers or liposomes, and using appropriate technologies and methods to encapsulate and protect the active pharmaceutical ingredients.

2) Another key strategy is to introduce some auxiliary substances into the oral delivery system, such as penetration enhancers or enzyme inhibitors, to help improve the absorption rate and stability of proteins/peptides. In addition, targeted delivery systems targeting specific targets can also improve the effectiveness of drugs and reduce dosage.

Workflow for Proteins & Peptides Oral Delivery System Development

• Determine the goal: Determine the goal of the developed protein/peptide oral delivery system, including the protein or peptide to be delivered, delivery method, delivery speed, delivery efficiency, etc.
• Determine the carrier: Determine the appropriate carrier according to the goal, which can be nanoparticles, polymers, liquid crystals, etc.
• Design the delivery system: Design a specific protein/peptide oral delivery system according to the goal and the selected carrier, including the structure and function of the carrier.
• Synthesize the carrier: Synthesize the required carrier according to the designed delivery system, and characterize and verify it.
• Protein/peptide modification: Modify the protein/peptide to be delivered to make it suitable for oral delivery.
• In vitro evaluation: Conduct cell experiments to verify the delivery effect and cell uptake efficiency of the delivery system.
• In vivo evaluation: Conduct animal experiments to verify the safety, stability, and delivery effect of the delivery system.
• Optimize and improve: Optimize and improve the delivery system according to the experimental results to improve delivery efficiency and stability.

Why Choose Us for Proteins & Peptides Oral Delivery System Development?

• We have extensive expertise and experience in executing the development of protein/peptide oral delivery systems.
• We master the latest expertise in therapeutic protein and peptide oral formulations and drug delivery systems.
• Support the development of a variety of therapeutic protein and peptide oral formulations, including but not limited to oral, tablet, capsule, liquid, etc.
• We provide flexible and tailored solutions to meet our customers' specific needs and requirements.
• Fast and efficient services ensure that our customers' projects are delivered on time.

Publication

CD Formulation is always at the forefront of protein/peptide oral delivery system development, mastering the most cutting-edge technologies and methods. Please don't hesitate to contact us if you are interested in our services.

How It Works

STEP 1

Submit a service request describing your specific research or development need.

STEP 2

We'll email you to provide your quote and confirm order details if applicable.

STEP 3

Execute the project with real-time communication, and deliver the final report promptly.