Cat.No.	Product Name	CAS	Inquiry
PE-0250	Dimethicone	9006-65-9	Inquiry

Product Introduction

Cooling agents are versatile and useful tools that provide cooling and refreshment in a wide range of consumer products. However, their safety and efficacy must be carefully evaluated before they can be approved for use in these products. CD Formulation offers high-quality products to its customers and can also provide professional product customization.

Why Choose Cooling Agents?

• Versatility

Cooling agents can be used in a wide range of consumer products, including oral care products and topical pain relievers. This versatility makes them a useful tool for providing cooling and refreshing sensations in a variety of different situations.

• Safety

Cooling agents are generally considered safe when used in appropriate concentrations in consumer products. However, high concentrations of some coolants, such as menthol, can cause skin irritation or other adverse effects in some people.

• Activation of receptors

Coolants work by activating sensory receptors in the skin or mucous membranes. The most common receptor activated by coolants is the TRPM8 receptor, which is responsible for detecting hypothermia.

• Stability

Cooling agents are generally stable and do not degrade or lose their cooling properties over time. This stability makes them a useful tool for providing stable and long-lasting cooling effects in consumer products.

How do Cooling Agents Work?

Cooling agents work by stimulating sensory receptors in the skin or mucous membranes to produce a cooling and refreshing sensation. When a cooling agent is applied to the skin or taken orally, it binds to TRPM8 receptors in sensory nerve endings. This binding activates the receptor, which triggers a series of chemical reactions that result in the sensation of cooling. The receptor is also sensitive to temperature changes, so when the coolant activates the receptor, it can produce the sensation of cold even if the actual temperature of the skin or mucous membranes does not change. In addition to activating the receptor, some cooling agents also act by rapid evaporation, which produces a cooling effect.