Finding the right excipients for semi-solid formulations can be difficult, and CD Formulation offers high-quality pharmaceutical excipients to expedite the formulation of semi-solid dosage forms for topical and transdermal delivery, among other applications. Semi-solid formulations typically include creams, lotions, ointments and gels.
The onset, duration and therapeutic effect of semi-solid formulations depend on several sequential processes: release of the active drug, penetration/diffusion of the drug through to the target layer, desired efficacy at the active site and maintenance of the drug concentration in the target area for a certain period of time. In addition, semi-solid formulations are generally lower in dose, and for low-dose drug formulations, the formulation research, process development and scale-up production, quality control and analytical method establishment are more difficult than conventional formulations. CD Formulation can provide customers with suitable excipients for semi-solid formulations in order to accelerate formulation development and drug research.
Semi-solid formulation excipients can provide important product characteristics, including:
According to the characteristics of the excipients and materials and their use in the formulation, the function-related indicators of the excipients and materials (especially those that may affect drug adhesion, permeability and bioavailability) should be studied and reflected in the material internal control standards.
For some key excipients such as macromolecular polymers, they should be controlled with their modifying group types, numbers, polymerization degrees, molecular weight distribution and other characteristic indicators, and attention should also be paid to the batch, suppliers and other factors that may affect the quality.