Excipients for Semi-solid Dosage Form

Excipients for Semi-solid Dosage Form

Finding the right excipients for semi-solid formulations can be difficult, and CD Formulation offers high-quality pharmaceutical excipients to expedite the formulation of semi-solid dosage forms for topical and transdermal delivery, among other applications. Semi-solid formulations typically include creams, lotions, ointments and gels.

The onset, duration and therapeutic effect of semi-solid formulations depend on several sequential processes: release of the active drug, penetration/diffusion of the drug through to the target layer, desired efficacy at the active site and maintenance of the drug concentration in the target area for a certain period of time. In addition, semi-solid formulations are generally lower in dose, and for low-dose drug formulations, the formulation research, process development and scale-up production, quality control and analytical method establishment are more difficult than conventional formulations. CD Formulation can provide customers with suitable excipients for semi-solid formulations in order to accelerate formulation development and drug research.

Features of Semi-solid Formulation Excipients

Semi-solid formulation excipients can provide important product characteristics, including:

  • Customized rheology modification and viscosity control.
  • Desirable appearance and feel for non-greasy creams, especially in clear gel products, and for other excellent semi-solid formulations.
  • Stable and consistent drug dispersion in semi-solid emulsions and suspensions.
  • Mucosal adhesion properties for improved bioavailability of active ingredients.
  • Compatible with acidic, basic and neutral drugs.
  • Thermal stability, allowing flexibility in final product sterilization.

Considerations for Semi-solid Formulation Excipients

According to the characteristics of the excipients and materials and their use in the formulation, the function-related indicators of the excipients and materials (especially those that may affect drug adhesion, permeability and bioavailability) should be studied and reflected in the material internal control standards.

For some key excipients such as macromolecular polymers, they should be controlled with their modifying group types, numbers, polymerization degrees, molecular weight distribution and other characteristic indicators, and attention should also be paid to the batch, suppliers and other factors that may affect the quality.

Online Inquiry
Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
Enter your email here to subscribe.

Easy access to products and services you need from our library via powerful searching tools.

Copyright © CD Formulation. All Rights Reserved.  Privacy Policy | Cookie Policy