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Stabilizers are substances added to a product to maintain its physical and chemical properties over time. In the pharmaceutical industry, stabilizers are used to improve the stability and efficacy of drugs. Stabilizers can help protect a drug from degradation, improve its solubility and bioavailability, and control its release time.
Polymers are large molecules composed of repeating units. They can be used as stabilizers for a variety of drug formulations. Polymers can improve the solubility, bioavailability and stability of drugs and also control the release time of drugs.
Cyclodextrins are cyclic sugar molecules that can be used to improve the solubility and stability of drugs. They can encapsulate drugs and protect them from degradation, as well as improve their bioavailability by increasing their water solubility. Cyclodextrins can also be used to modify the pharmacokinetics of drugs, such as prolonging their circulation time in the body.
Chelating agents are compounds that can bind to metal ions, which can catalyze the degradation of drugs. Chelating agents can be used as stabilizers for various drug formulations, such as parenteral formulations.
The choice of stabilizer depends on the specific drug and the properties it requires. Each stabilizer has its own advantages and disadvantages and should be carefully considered when choosing a stabilizer to ensure that it is safe, effective, and acceptable to the patient.
Stabilizers can improve product stability by preventing degradation, separation, precipitation, or other unwanted changes that may occur over time. Stabilizers can help maintain the physical and chemical properties of the product, such as texture, appearance, and pH, to ensure product efficacy and safety.
Stabilizers can improve the solubility of a drug or other substance by increasing its water solubility or dispersibility. This can improve the bioavailability of the drug and make it more effective in the body.
Stabilizers can improve the emulsification of products such as oil-in-water or water-in-oil emulsions. This improves the stability and appearance of the product and prevents separation of the phases.
Some stabilizers have antimicrobial properties and can act as preservatives to prevent the growth of bacteria, fungi or other microorganisms in products. This can improve the shelf life and safety of the product.