Increased Bioavailability Excipients

CD Formulation has professional production equipment and management experience, and has professionals with rich professional knowledge. We can customize increased bioavailability excipients of different specifications and quality requirements, and produce corresponding products according to customer requirements.

Background of Increased Bioavailability Excipients

Background of Increased Bioavailability Excipients

Most of the apis have poor water solubility, and the dissolution of insoluble substances can be effectively improved by adding excipients. Generally, oral drugs need to be dissolved in gastric juice before they can be better absorbed. Enhancing the dissolution rate of drugs can improve the bioavailability of drugs. Dissolution is the rate control phase of the drug, which controls the rate and extent of drug absorption. In general, poorly soluble oral drugs dissolve slowly, absorb inconsistently or incompletely, and may result in low bioavailability. As it stands, low water solubility is a major challenge in drug development and delivery.

Several techniques are being used to improve the bioavailability of low-water-soluble pharmaceutical compounds, including:

  • Solid dispersion
  • Micronization
  • Solvent evaporation
  • Ordered mixing
  • Solvent deposition inclusion
  • Steam assisted granulation

Most of the above technologies require excipients as carriers, and the bioavailability of drugs can be greatly improved by increasing the occurrence agents.

Classification of Increased Bioavailability Excipients

Many excipients have acceptable regulatory and safety profiles and can be screened as carriers for low bioavailability hydrophobic drug delivery and optimal drug dissolution. Excipients come in contact with water to form finely dispersed substances that improve drug bioavailability. At present, the main excipients that can improve bioavailability are as follows:

Carbohydrate

Carbohydrate-based parenteral excipients, such as trehalose, sucrose, mannitol, sorbitol and maltose, enable formulation scientists to stabilize large and small molecule injection therapies that would otherwise be unavailable in the clinic due to low solubility and/or bioavailability.

Polymer

Polymer excipients stabilize amorphous drugs in a solid state and then remain supersaturated in the aqueous phase. Polymer excipients can also be used to control the release of drugs upon dissolution. For example, povidone and hydroxypropyl succinate, as part of a broad range of cellulose and vinylpyrrolidone polymers, have excellent extrudability and controlled release properties.

Surface Active Agent

Surfactant as an excipient can promote the solubilization of lipophilic drugs by micelle formation or as a cosolvent. For example, polyethylene glycol glycerol can be used to prepare lipid-based formulations that significantly improve solubility and thus oral bioavailability through various self-emulsifying systems.

The Advantages of Increased Bioavailability Excipients

Poor or volatile drug absorption is associated with low intestinal permeability or low water solubility of active pharmaceutical ingredients. Nowadays, adding excipients to drugs has become a successful method to improve the solubility of drugs in the dosage form, or improve the solubility of drugs in the gastrointestinal tract (GI), regulate drug absorption and improve bioavailability.

It has the following advantages:

  • Improve the solubility of active pharmaceutical ingredients in the dosage form.
  • Maintain the dissolved state of the API in the gastrointestinal tract.
  • Cooperate with the digestion and absorption of physiological lipids in the body to promote the absorption of drugs.

The Advantages of Increased Bioavailability ExcipientsFig. 1 The Advantages of Increased Bioavailability Excipients

If you have any requirements for increased bioavailability excipients, please contact us by phone or email, and our colleagues will reply to you within 2-4 working days.

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