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Solubilizer (for injection) is a substance that is added to a drug to increase its solubility in water or other solvents. Because many drugs are insoluble in water, this can make them difficult to administer to patients by injection.
Solubilizers work by changing the structure of drug molecules, usually by encapsulating them in micelles or forming complexes with drug molecules. Common solubilizers used in injectable formulations include surfactants, as well as co-solvents. These solubilizers can improve the bioavailability and efficacy of the drug and help reduce the risk of adverse reactions. The choice of solubilizers and their concentrations must be carefully considered during the formulation process to ensure the safety and efficacy of the final product.
Solubilizers are commonly used in injectable formulations to increase the solubility of insoluble drugs.
Surfactants are molecules that have both hydrophilic (water attracting) and hydrophobic (water repelling) properties. They act by forming micelles around the drug molecules, with the hydrophobic part of the surfactant molecule facing toward the drug and the hydrophilic part facing outward.
Cyclodextrins are cyclic oligosaccharides that form inclusion complexes with a variety of guest molecules, including drugs. They act by encapsulating drug molecules within the cavities of cyclodextrin molecules, thereby increasing their solubility in water or other solvents.
Lipid-based solubilizers are used for drugs that are lipophilic in nature. They work by forming a complex with the drug molecule, thus increasing its solubility in water or other solvents.
Solubilizers (for injection) work by increasing the solubility of insoluble drugs in water or other solvents so that they can be administered by injection. A micelle is a structure formed by surfactant molecules in which the hydrophobic part of the molecule is on the inside of the structure and the hydrophilic part is on the outside. When a poorly soluble drug is added to a solution containing a solubilizing agent such as a surfactant, the surfactant molecules can form micelles around the drug molecules with the hydrophobic portion of the surfactant molecules facing toward the drug and the hydrophilic portion facing outward. This encapsulation of the drug molecule within the micelles increases its solubility in water and allows it to be administered by injection.