Filler Excipients

CD Formulation provides customers with fillers that play an important role in slow and controlled release. It is suitable for the production of pills, slow and controlled release medicament, health care products and cosmetics. We can customize different specifications and quality requirements of filling agent, and according to the prescription of customers to produce the corresponding products. At the same time, we can provide professional guidance and suggestions for the application of pharmaceutical excipients to drugs.

About Fillers

Fillers increase the volume of the product and make very small active ingredients easy for consumers to take. The filler is added to the material to improve the performance of the material, or can increase the volume, increase the weight, and reduce the cost of the solid material. The filler combines and stabilizes the supplement. They do not change or affect the effectiveness of the active pharmaceutical ingredient (API). Generally, organic, inorganic, metal or non-metal powders that do not contain water, are neutral, and do not play a negative role with the material components can be used as fillers. The main function of the filler is to fill the weight or volume of the tablet to facilitate compression.

Classification of Fillers

Commonly used fillers include starches, sugars, celluloses and inorganic salts.　　

Starch

High quality and low price, corn starch is more commonly used. The compressibility is poor, and if it is used alone, the pressed tablets will be too loose. Mix starch, powdered sugar and dextrin. It is also used as a disintegrant, and starch slurry is used as a binder.　　

Powdered Sugar

Strong adhesion, strong hygroscopicity, high tablet hardness, multi-used in buccal tablets and soluble tablets (flavoring effect).　　

Dextrin

The hydrolysate of starch has strong adhesion, high hardness and strong adsorption. The dosage should be small, and it is better to use it in combination with powdered sugar (it is easy to cause pitting and watermark on the tablet).

Lactose

It is an excellent tablet filler. No hygroscopicity, suitable for drugs with hygroscopicity. It has good fluidity and compressibility and can be used for direct compression of powder. It is expensive and rarely used alone.　　

Compressible Starch

Also known as pregelatinized starch, it has good fluidity, compressibility, self-lubricity and dry adhesion, and has a good disintegration effect.　　

Microcrystalline Cellulose (MCC)

It has good compressibility and strong binding force. It can be used as a "dry binder" for direct powder compression.　　

Inorganic Salts

Mainly inorganic calcium salt, calcium sulfate is commonly used, and calcium sulfate dihydrate is often used in tablet excipients. However, it should be noted that calcium sulfate interferes with the absorption of certain main drugs (tetracycline drugs) and should not be used at this time.　　

Mannitol

Mannitol has poor liquidity and is expensive. More suitable for preparing chewable tablets.

Fig. 1 Classification of Fillers

CD Formulation is a high-tech company integrating R&D, production and sales of pharmaceutical excipients. The company insists on taking science and technology as the guide, and constantly develops new products to inject new vitality into development. In terms of pharmaceutical excipients, we provide materials including binders, colorants, diluents, disintegrants, emulsifiers, lubricants, plasticizers, surfactants, fillers, stabilizers and other materials. If you are interested in our products, welcome to contact us for more detailed information.