Inclusion compounds are supramolecular complexes in which one molecule is encapsulated within the cavity of another molecule. The host molecule is usually a macrocycle or a cyclic oligomer, while the guest molecule can vary considerably depending on the application.
Inclusive compounds can be designed to release guest molecules in a controlled manner, which can be useful in drug delivery or other applications. For example, the release rate of a drug molecule can be controlled by adjusting the size and shape of the host molecular cavity.
Inclusion compounds can increase the solubility of a guest molecule in water or other solvents by encasing the guest molecule in the cavity of the host molecule. This is useful in a variety of applications, such as improving the bioavailability of drugs or improving the stability of dyes and fragrances.
Inclusion complexes are usually stable and have a high degree of structural integrity, which makes them useful in a variety of applications. The stability of inclusion complexes is due to specific interactions between the host and guest molecules, including hydrogen bonding, van der Waals forces and electrostatic interactions.
Inclusion complexes can be formed using a wide range of host and guest molecules, which makes them a versatile tool in supramolecular chemistry. This versatility allows the design of inclusion compounds with a wide range of properties and applications.
Due to their unique properties, inclusion compounds have a wide range of applications in various fields. For example, drug delivery, inclusion compounds can be used to improve the solubility, stability and bioavailability of drugs. For example, cyclodextrins are often used as solubilizers to improve the bioavailability of insoluble drugs. Inclusion compounds can also be used for targeted controlled release of drugs, which can improve their efficacy and reduce side effects.