Services List

Solubility Improvement and Bioavailability Enhancement Services

Bioavailability refers to the degree and speed at which a drug is absorbed into the blood circulation. There are ongoing challenges with poorly water-soluble drugs and have failed to reach the market due to their poor water solubility. CD Formulation has developed a range of technologies and formulation expertise to improve the solubility and bioavailability of these drugs, helping customers find the right way to commercialize their drug products. This experience, along with a variety of techniques, enables CD Formulation to overcome many of the hurdles surrounding solubility and bioavailability, including physical, chemical, encapsulation techniques and so on.

Dissolution of drugsFig. 1 Dissolution of drugs

Our Services

Every formulation is unique, just as every drug candidate is unique. We always keep in mind the target product profile and the final desired dosage form, so as the molecule progresses through the development process, the drug product strategy is robust with a scalable process to avoid any delays later in development. Our goal is to optimally match technologies that enhance drug solubility and bioavailability with our clients' corporate goals, timelines and budgets. Services we provide include:

Our CD Formulation team is a leading expert in all aspects of pharmaceutical formulation development and dosage form optimization, providing you with a one-stop shop where we can improve drug bioavailability and solubility based on API characteristics and customer development goals. If you have poorly soluble or insoluble drugs, please contact our staff and we will determine the most appropriate way to assist your drug development.

The Advantages of Our Services

CD Formulation can help you solve the challenges associated with insoluble APIs, enabling you to:

  • Develop delivery technologies for lifecycle management.
  • Improved safety and effectiveness.
  • Reduce development time and cost to increase profitability.
  • Bring new products to market - faster.
  • Improve patient compliance.
  • Create new ways to revitalize failed/discontinued products.

The advantages of CD Formulation for solubility improvementand bioavailability enhancement services

How to Contact Us?

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

  1. Wong, S M.; et al. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant containing microparticles. Int J Pharm, 2006, 317(1):61-68.
  2. Patravale, V B.; et al. Nanosuspensions: a promising drug delivery strategy. Pharm Pharmacol, 2004, 56(7): 827-840.
  3. Nielsen, A B.;et al. Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug. European Pharm Sci, 2005, 24:85.

Online Inquiry

Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!

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