Moisture Content Determination

The presence of moisture will affect the chemical and physical properties of the final product. Excessive moisture can cause the powder particles to agglomerate and make the tablets brittle. Too little moisture can cause tablets to scatter. Powdered excipients may not flow if they are too wet, and some active pharmaceutical ingredients (API) may crystallize or change form if there is too much moisture. The production method of solid dosage form includes freeze-drying, fluidized bed drying, compaction, granulation and extrusion. All of these operations depend on the amount of moisture present and the state, moisture also affects the chemical/physical properties of individual active ingredients and excipients. Therefore, accurate determination of moisture content is very important to ensure the quality of drugs.

Common types of contact drying equipment.Fig.1 Common types of contact drying equipment.

CD Formulation can provide you with moisture content determination services of APIs and inactive ingredients, and our scientists will help you to make a decision for operational and procedural conditions that can ensure the physical and chemical stability and pharmacological activity of the product to minimize potential formulation and stability issues.

Moisture Sources of Dosage Forms

  • Bulk drug
  • Manufacturing processes
  • Inactive excipients
  • Environmental conditions

Our Methods for Moisture Content Determination

Methods
Drying methods Direct determination
Absorption of water in a suitable drying agent (desiccant is measured before and after absorption)
Indirect determination - mass loss of the sample
Drying of the samples under precisely defined conditions -, methods in an oven method
Exposing the sample to dry atmosphere (as in a desiccator)
Routine methods Method with NIR (Near Infrared Reflectance) analyzer
Method with NIT (Near Infrared Transmission) analyzer

Deliverable

  • Data analysis
  • Provide full study report

Our Advantages

Moisture Content Determination

How to Contact Us?

If you have a requirement about moisture content determination services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

  1. Mainali D, Li J, Yehl P, et al. Development of a Comprehensive Near Infrared Spectroscopy Calibration Model for Rapid Measurements of Moisture Content in Multiple Pharmaceutical Products[J]. Journal of Pharmaceutical and Biomedical Analysis, 2014, 95: 169-175.
  2. Marjanović-Balaban Ž, Jelić D, Antunović V, et al. Determination of Water content in Pharmaceutical Substances[J]. Journal of Hygienic Engineering and Design, 2013.

Online Inquiry

Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!
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