Loss-on-Drying Test

CD Formulation provides loss-on-drying testing to determine the amount of volatile substances in tablets, capsules or bulk materials. CD Formulation offers a one-stop service for testing the physical and chemical parameters of drugs, providing a rapid response to your testing needs and a credible test report.

About Loss on Drying of Drugs

Loss-on-drying (LOD) is determined by heating a sample in an oven to a temperature below its melting point and includes all volatile substances, including water content and solvents. Loss on drying is a non-specific analytical technique that removes not only water from the sample, but also all other volatile impurities such as alcohol. The degree of drying depends on temperature and drying time. analysis of the total water content of an LOD or drug product can include both bound water (e.g. hydrated water) and free water. Since other volatile impurities may be present in the drug, e.g., alcohol; all, the LOD may be higher than the water content.

% LOD check formula:

% LOD check formula

Loss-on-Drying Test Method


Once placed in a room or convection oven, the sample is repeatedly weighed according to a preset schedule and the weight loss is recorded. Once the weight remains constant, the difference between the initial weight and the final weight is calculated, corresponding to the evaporated moisture. This is used to calculate the percentage of moisture.

Loss-on-Drying Test

Microwave Drying

This is another weight method that uses several steps to dry the sample while performing repeated weight measurements. Microwave heating and evaporation of the moisture in the sample is very fast and takes only a few minutes. In addition, the sample size does not have to be very small.

Infrared Drying

Infrared radiation or heat can also be used to determine the moisture content of a sample, but only for small samples weighing 0.1 to 120 grams.

Loss-on-Drying Test

Moisture Meters

Moisture tester is a device for determining the moisture content using the loss-on-drying method and consists of a weighing and h alogen heating unit. It is suitable for quality control and production needs in pharmaceutical and chemical industries.

Our Services

CD Formulation provides professional loss-on-drying testing services to help you analyze the moisture content of your pharmaceuticals as well as other volatile substances. The loss-on-drying analysis can be used to analyze the shelf life of your drug, which can lead to better drug development and process optimization.

Our Advantages

  • As a leader in the testing industry, we provide comprehensive one-stop solutions in the pharmaceutical field. We have cooperated with many companies and have rich experience.
  • We always follow the most authoritative laws and regulations for pharmaceutical formulations to ensure that test data and protocols meet the specified requirements.
  • We have very professional laboratory technicians and operators with fully equipped laboratories.
  • Our prices are competitive and worthy of our customers' choice.

About CD Formulation

CD Formulation's business covers all aspects of drug formulation, drug ingredients, drug development, drug testing, drug optimization, etc. We provide one-stop integrated services from pre-clinical to commercial manufacturing for our global pharmaceutical and biotech partners. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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