CD Formulation provides professional pH testing of medications, usually we test liquid medications, including injections, eye drops, etc. By testing the pH of a drug, we can determine whether it is suitable for use in the human body and avoid pain or poisoning caused by too high or too low pH.
Since the pH value varies in different parts of the organism, for example, the pH value of serum and tear fluid is about 7.4, the pH value of gastric fluid is about 0.9~1.2, the pH value of bile is about 5.4~6.9, and the pH value of plasma is 7.4. However, when the pH value of a drug solution deviates too far from the normal pH value of the body fluid concerned, it tends to cause irritation to the tissues, therefore, when preparing infusions, injections, eye drops and solutions for wounds, attention must be paid to the pH of the drug solution. The pH of injection solution should be in the range of 4~9, otherwise it will cause pain and tissue necrosis; the pH of eye drops should be 6~8. The pH value used should consider the effect of pH on drug stability and drug solubility.
Usually, the factor that affects pH is temperature.
The determination of pH value of drug solution is generally performed by pH meter with glass electrode as the indicator electrode and a cell composed of glycury electrode as the reference electrode.
The pH value varies with the temperature of the solution in the measuring cell. Therefore, the pH meter is equipped with a temperature compensation knob.
To use the pH meter, the instrument must be pre-calibrated (positioned) with a standard buffer and adjusted with the positioning knob so that the pH indication is the same as the pH value of the standard buffer.
After the temperature compensation adjustment and positioning adjustment, change the solution to be measured for determination, and the pH meter will indicate the pH value of the test solution accurately.
The following points should be noted during the test
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