Services List

Coated Microneedles Technology Services

Coated microneedles refer to the coated of a drug solution or a drug dispersion layer onto the surface of a solid microneedle, which results in a coated microneedle. The preparation of coated microneedles consists of 3 steps: preparation of solid microneedles, preparation of drug solution, and coated the drug on the microneedle surface. Since the antigen dose required to trigger an immune response is usually at the nanogram or microgram level, coated microneedles offer unique advantages for vaccination.

Diagram of a coated microneedle.Fig.1 Diagram of a coated microneedle. (Rn et al., 2020)

Preparation Method

Different methods can be used in the process of attaching the drug to the microneedle. These methods include the following:

  • Dip-coated method
  • Gas jet drying method
  • Spray coated method
  • Electrohydrodynamic atomization method
  • Piezoelectric inkjet printing method

Our Services

CD Formulation provides integrated services from drug development to drug delivery, which can help our clients better develop their drug products. Our coated microneedle technology is well suited to coat a wide variety of active substances, including small molecules, peptides, proteins, deoxyribonucleic acids and viruses, onto microneedles for delivery to different tissues and organs. Here, we provide optimized services and testing services for the steps involved in coated microneedle technology.

1. Coated Excipient Solutions

CD Formulation provides coated excipient options for pharmaceutical customers in screening the appropriate delivery method for their drugs. The coated excipients we select for our clients are consistent with the drug's properties and need to meet the requirements of good biocompatibility, solid state at room temperature and minimal use.

2. In Vitro Characterization and Strength Testing of Coated Microneedles

In Vitro Characterization

Provides data on the homogeneity of the coated, the "effectiveness" of the drug and the efficiency of delivery for evaluation of microneedles.

Strength Testing

Provides physical parameters of microneedles, including: microneedle viscosity, microneedle strength, microneedle bending resistance evaluation, microneedle substrate hardness, microneedle molding quality and reliability verification, microneedle inter-slice consistency, and microneedle inter-face consistency.

Diagram of a coated microneedle.

Advantages of Coated Microneedle Technology

  • Higher bioavailability by delivering the drug directly to the site of the disease.
  • Less damage to the body, no nerve irritation and less pain.
  • Easier dose control.

Types of Drug Delivery

The types of drug delivery that can be performed by coated microneedles include:

Fluorescein, calcein, vitamin B, trichothecene, insulin, desmopressin, parathyroid hormone, bovine pancreatic ribonuclease, ovalbumin, bovine serum albumin, horseradish peroxidase, antisense oligonucleotides, herpes simplex virus, West Nile virus, luciferase plasmid DNA, vaccines, salmon calcitonin, epinephrine, mepacaine, interfering ribonucleic acid, recombinant human growth hormone, paclitaxel, anticancer drugs, interferon, etc.

How to Contact Us?

If you have a requirement about our coated microneedles technology services, please contact us by phone or email, our colleagues will reply to you within three working days.

Reference

  1. Rn, A , et al. A review of recent advances in microneedle technology for transdermal drug delivery[J]. Journal of Drug Delivery Science and Technology, 2020, 59.

Online Inquiry

Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!

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