Ferritin is an iron storage protein that is widely found in almost all living organisms and has the functions of storing and converting iron, maintaining cellular iron metabolic homeostasis, and protecting cells from oxidative damage. Ferritin subunits are capable of self-assembling into nanocages to load and transport drugs.
CD Formulation can provide customers with enhanced ferritin modification services, including folic acid, photosensitizers, etc., which can be loaded into ferritin to enhance the targeting of drugs.
CD Formulation improves the characterization of ferritin with a range of physical and chemical properties such as particle size, zeta potential determination, morphology determination, and iron content determination.
CD Formulation assays the drug loading rate, encapsulation rate, protein concentration, and in vivo release of ferritin nanoparticle delivery systems to improve customer-tailored solutions for better drug development and effective delivery.
As a carrier, ferritin has a particle size of 12 nm, which makes it easy to escape phagocytosis by the reticuloendothelial system in the blood circulation, with a long circulation time and a long half-life. It can also be used to enhance the drug accumulation at the lesion site by enhancing the permeation and retention effect and enhancing the drug efficacy.
Ferritin is a naturally occurring protein from living organisms with low toxicity, good biodegradability and biocompatibility, and is not prone to rejection reactions.
Ferritin is highly tolerant to temperature and pH and can maintain its original hollow structure over a wide pH range and can be maintained at a high temperature of 75°C for 10 minutes.
Innate tumor targeting: after drug administration, it is effectively enriched in tumor tissues due to EPR effect during the blood circulation.
Ferritin is used as a delivery system to load chemical drugs, which can effectively avoid the rapid clearance of drugs in the body, prolong the half-life of drugs, reduce drug dosage, and also enable targeted drug delivery to improve the effect of drug uptake by cells.
Nucleic Acid or Peptide Drug Delivery Systems
Ferritin can be used as a delivery vehicle for gene drugs. Currently, nucleic acid drugs available for delivery include siRNA, miRNA and sgRNA.
CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.