Particle Size Analysis

The particle size distribution of active ingredients and excipients is an important physical property of materials used to manufacture pharmaceutical products. The size, distribution and shape of the particles will affect the overall performance, stability and appearance of the final product. Therefore, particle size monitoring is essential for the entire drug development and manufacturing process.

Particle Size AnalysisFig.1 Particle morphology (Shekunov B Y, et al. 2007).

CD Formulation can provide you with comprehensive particle size analysis services of active ingredients and excipients, and our scientists will help you to make a decision for operational and procedural conditions that can ensure the physical and chemical stability and pharmacological activity of the product to minimize potential formulation and stability issues.

Our Techniques for Particle Size Analysis

Technique Method Effective Measuring Range, μm Most Representative PSD
Optical image analysis Direct imaging 3 - 150 Number-weighted
SEM Direct imaging 0.01 - 150 Number-weighted
LD Low-angle (Fraunhofer) diffraction rings measurement 0.5 - 1,000 Volume-weighted
DLS Measurement of light intensity correlations from particles in Brownian motion 0.003 - 3 Volume-weighted
Coulter counter Electrical zone-sensing 0.6 - 1,200 Volume-weighted
TOF Measurement of particle velocity in expanding air flow 0.5 - 200 Number-weighted
CI Inertial particle impaction as a function of air velocity 0.5 - 10 Mass-weighted

SEM: Scanning electron microscopy; LD: Laser diffraction; DLS: Dynamic light scattering; TOF: Time-of-flight; CI: Cascade impactor.

Our Advantages

Particle Size Analysis Advantages

How to Contact Us?

If you have a requirement about particle size analysis services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

  1. Shekunov B Y, Chattopadhyay P, Tong H H Y, et al. Particle Size Analysis in Pharmaceutics: Principles, Methods and Applications[J]. Pharmaceutical Research, 2007, 24(2): 203-227.
  2. Bauer J F. Pharmaceutical Solids: Size, Shape, and Surface Area[J]. Journal of Validation Technology, 2009, 15(1): 37-45.

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Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!
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