Ophthalmic suspensions are used to deliver poorly soluble compounds and are sterile liquid preparations containing solid particles dispersed in a liquid carrier. Such suspensions must contain the drug in micronized form to prevent irritation and/or scratching cornea. CD Formulation's team are leading experts in all aspects of pharmaceutical dosage form development and dosage form optimization, and we can design suspension dosage forms based on the properties of the API and the client's development goals. CD Formulation can be your one stop shop for your suspension dosage form needs.
The services provided by CD Formulation are:
Our CD Formulation team is a leading expert in all aspects of pharmaceutical formulation development and dosage form optimization, and can design formulations for suspensions based on API properties and customer development objectives.
Most formulation considerations for ophthalmic dosage forms are similar to those described for general drug solutions, and the main considerations for suspensions are as follows:
Ideally, viscosity modifiers should have the following properties:
- Easy to Filter: All eye drops are filtered during the manufacturing process.
- Ease of Sterilization: Sterilization of eye drops is usually performed by filtration (see above) or by heating.
- Compatibility with Other Ingredients: Pharmaceutical scientists must ensure that there is no or only limited interaction between the therapeutic agent and the viscosity modifier.
1. Direct application of the therapeutic agent to the site of action ensures that the therapeutic agent is available at a higher concentration than may be achieved after oral administration.
2. Topical application of therapeutic agents ensures that the incidence of side effects is minimized.
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