Liquid-solid compression, also known as solution powder making, involves dissolving a water-insoluble drug in a non-volatile liquid excipient and then mixing it with a suitable carrier and coating material to make a non-viscous, a stable compressible powder in which the drug is present in the liquid excipient in the form of a refractory solid drug or a fat-soluble liquid drug. Compared with poorly soluble drugs with high drug loading, it is more ideal to use poorly soluble drugs with low drug loading as model drugs. Also, drugs are generally dissolved in liquid excipients in a molecular or amorphous state. CD Formulation provides liquid-solid compression services, including compatibility research, determination of drug particle morphology, pre-compression evaluation and post-compression evaluation to help customers better develop drugs.
Fig.1 Liquid solid compression preparation process flow chart
Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were used to study physicochemical interactions between drugs and liquid excipients, revealing formulation compatibility.
Determination of Drug Particle Morphology
X-ray diffraction and DSC are used to study any complex formation between the drug and the liquid excipient and any changes in crystal form during the manufacturing process, while scanning electron microscopy (SEM) can show the liquid-solid system during the manufacturing process The form in which the drug exists.
Evaluation Before Compression
In order to obtain uniform and reproducible tablet fillings, the flowability of the powder in the product of the pharmaceutical formulation is critical, otherwise, the flowability will change at high doses. In order to make the liquid-solid system have good fluidity and compressibility, the system will be compressed into tablets and evaluated, generally using the angle of repose, Carr's index and Hausner ratio as evaluation indicators.
After compression, tablet uniformity, hardness, weight variation, friability, disintegration time, and in vitro dissolution testing will be re-evaluated.
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