Lipid-Based Nanoparticles Development Services for Drug Delivery Systems

Liposomal nanoparticles (LNPs) are a type of drug delivery system with a homogeneous lipid core of lipid vesicles that are widely used for the delivery of drugs such as small molecules and nucleic acid drugs. The lipid composition of liposomal nanoparticles usually includes four types: ionizable lipids (or cationic lipids), auxiliary lipids, cholesterol, and polyethylene glycolized lipids (PEG-lipids). Lipid nanoparticles can be classified according to their structure and drug delivery mechanism: solid lipid nanoparticles, nanostructured lipid carriers, lipid-drug conjugates, and polymeric lipid-hybrid nanoparticles.

The liposome nanoparticle system has outstanding advantages as a drug delivery vehicle, which combines the advantages of liposomes and nanoparticles with the following characteristics:

• High drug encapsulation rate, adjustable sustained release behavior and good serum stability for a wide range of cell and tissue targeting.
• The core-shell structure of liposome nanoparticle assemblies allows the core to act as a container for hydrophobic drugs and the shell to protect the drug and achieve a slow release.
• Liposomal nanoparticles are non-viral carriers that are not immunogenic and do not cause immune reactions in cells, and when wrapped, they can protect gene-based drugs from enzymatic degradation to reach cells and can be used as biological drug carriers.

Preparation Techniques of Lipid-Based Nanoparticles

Thermal homogenization method, cold homogenization method, microemulsion method, microwave-assisted microemulsion method, solvent evaporation method, compound emulsion method, dissolution-diffusion method, solvent injection method, high shear homogeneous ultrasound method, membrane contact method, emulsion supercritical fluid extraction method, coalescence method, phase transition temperature method.

Our Services

CD Formulation provides complete lipid-based nanoparticles technology services, including liposome nanoparticle characterization, development and technical solutions to assist pharmaceutical customers in the drug discovery process.

Characterization of Liposomal Nanoparticles

CD Formulation has advanced instrumentation for the physical and chemical characterization of liposomal nanoparticles, including particle size, surface charge, chemical composition and morphology.

Liposomal Nanoparticle Technology Development Services

CD Formulation's experimental staff has expertise and experience in liposomal nanoparticle technology development, providing solutions for clients from liposome composition development to final drug release pathway development process. We offer a full range of liposomal nanoparticle technology services to help our clients in the healthcare industry.

Our Services including the following:

• Customized Lipid Microparticles System Services
• Customized Lipospheres Drug Delivery Formulation Services
• Customized Lipid Drug Conjugates Drug Delivery System Services

Characterization Instruments

• Particle size and zeta potential measurements
• X-ray photoelectron spectroscopy (XPS)
• Microscopy techniques
• Transmission electron microscopy (TEM) of ultra-thin sections
• Differential scanning calorimetry (DSC)
• Freeze-Etch Electron Microscopy

Applications of Lipid-Based Nanoparticles

• Drug targeting
• Combination drug delivery
• Gene therapy drug carriers
• Ophthalmic drug carriers

About CD Formulation

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.