pH Modification Drug Molecular Services

The solubilization of poorly soluble drugs is a challenge often encountered in the screening of new chemical entities and the design and development of formulations. Orally administered drugs can only be completely absorbed when they show good solubility in gastric media and have good bioavailability. Bioavailability depends on several factors. The solubility of the drug in an aqueous environment and the permeability of the drug through the lipophilic membrane are important factors. The pH adjustment method is a technique that increases the solubility of ionizable API by adding acidic and alkaline excipients to the formulation.

The solubilization of poorly soluble drugs

CD Formulation provides a complete set of services for the development and manufacturing of improved drug solubility and bioavailability, including the provision of pH regulators, drug solubility evaluation, etc. We have quality systems, infrastructure, and capabilities to create a low-risk path for commercial production even with the most complex formulations.

Our Services

Most drugs have poor solubility and low bioavailability before entering the market. Adding pH regulators is the way to solve this problem. Our research team is committed to solving drug development problems for customers and providing pH adjustment project services, including:

A variety of pH regulators are available for screening, including acidic and alkaline excipients and buffer solvents, etc.

Process development for the production of pH-regulated drugs, screen out suitable pH regulators, and then conduct drug solubility testing and development of a series of processes for drug efficacy evaluation.

Analytical method development, to test the solubility and bioavailability of drugs, it is necessary to develop appropriate analytical methods, including solubility testing, etc.

A customized solution for pH regulators. This innovative solution can meet the strict process requirements of users and accelerate the clinical application of the project.

Reliable Supply Chain

We create more value for you through a reliable supply chain of key raw materials. You can arrange and plan your research and production needs with us to simplify the procurement process and ensure that your work is carried out smoothly.

Strict Quality Control

We always put quality first. In order to ensure reliability, data traceability, safety and quality, we adopt a strict quality control process at every step. From excipients to customized pharmaceutical excipients, our strict process monitoring can enable you to explore new areas.

The Advantages of Our Services

The Advantages of CD Formulation for pH modification drug molecular services

How to Contact Us?

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.


  1. Badawy S., Hussain M. A. Microenvironmental pH modulation in solid dosage forms[J]. Journal of Pharmaceutical Sciences, 2007, 96(5): 948-959.
  2. Tatavarti A. S., Hoag S. W. Microenvironmental pH modulation based release enhancement of a weakly basic drug from hydrophilic matrices[J]. J Pharm, 2006, 95(7): 1459-1468.
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Please note: Our products and services are not intended to be used directly in diagnostic or therapeutic procedures.
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