Services List

Microsphere Technology Development Services

Sustained-release microspheres are spherical entities with particle size distribution between 5 and 250 μm formed by dissolving or dispersing the drug in a polymeric matrix. Among the many existing extended release formulations, microspheres have unique advantages such as gradual release of the drug by degradation of the microspheres after administration, avoidance of blood concentration peaks and valleys, reduction of the dose during the therapeutic cycle, and improvement of the bioavailability of the drug and patient compliance.

SEM image of microspheres.Fig. 1 SEM image of microspheres. (Wu et al., 2019)

Advantages of Microspheres

  • Delayed release of microspheres can be up to half a year, greatly improving patient compliance by reducing the frequency of administration.
  • Microspheres are slowly released at the site of administration to maintain effective blood concentration, reduce blood concentration fluctuations, and reduce toxic side effects.
  • Microspheres have special affinity with certain cells and tissues, and can be endocytosed by the reticuloendothelial system of tissues and organs to achieve targeting.
  • Microspheres are mainly used for peptide drugs. Compared with the mature chemical drugs, peptide drugs have more room for development and more market potential.
  • The route of administration of microspheres is injection, bypassing the first-pass effect, improving bioavailability and reducing the dose of drug delivery.

Our Services

Delayed Release Microsphere Technology Services

CD Formulation develops microsphere technology and microsphere preparation processes based on a thorough understanding of the physicochemical properties of the loaded drugs (small molecule compound classes, peptides, proteins, herbal fractions, etc.), and then enables better delivery of the drugs produced by our customers to facilitate their development in the healthcare industry.

Characterization of Physical Properties of Microspheres

CD Formulation provides physical characterization, including morphology, particle size and distribution, organic solvent residues, polymer glass transition temperature and crystal shape changes.

Pharmacological Evaluation of Microspheres

CD Formulation provides pharmacological evaluation of microspheres including drug loading/encapsulation rates, release behavior, material degradation assays, and microbial examination.

What Makes Microsphere So Attractive for Drug Delivery Systems?

SEM image of microspheres.

A successful drug delivery system must not only deliver the drug at the correct dose, but also to the intended target in the patient's body with proper timing to ensure maximum therapeutic efficacy. Microspheres are an attractive drug delivery system because they are made of biodegradable polymers that do not harm the body and can hold a wide variety of drugs that can be delivered to the patient with a simple injection. In addition, microspheres can ensure controlled delivery of active drug ingredients, making them an attractive procedure for biomedical scientists and healthcare professionals.

About CD Formulation

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

Reference

  1. Wu, Wei Bing , et al. Fluorescent polystyrene microspheres with large Stokes shift by fluorescence resonance energy transfer[J]. Journal of Physics and Chemistry of Solids, 2008, 69( 1):76-82.

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Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!

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