Sustained-release microspheres are spherical entities with particle size distribution between 5 and 250 μm formed by dissolving or dispersing the drug in a polymeric matrix. Among the many existing extended release formulations, microspheres have unique advantages such as gradual release of the drug by degradation of the microspheres after administration, avoidance of blood concentration peaks and valleys, reduction of the dose during the therapeutic cycle, and improvement of the bioavailability of the drug and patient compliance.
Fig. 1 SEM image of microspheres. (Wu et al., 2019)
Delayed Release Microsphere Technology Services
CD Formulation develops microsphere technology and microsphere preparation processes based on a thorough understanding of the physicochemical properties of the loaded drugs (small molecule compound classes, peptides, proteins, herbal fractions, etc.), and then enables better delivery of the drugs produced by our customers to facilitate their development in the healthcare industry.
Characterization of Physical Properties of Microspheres
CD Formulation provides physical characterization, including morphology, particle size and distribution, organic solvent residues, polymer glass transition temperature and crystal shape changes.
Pharmacological Evaluation of Microspheres
CD Formulation provides pharmacological evaluation of microspheres including drug loading/encapsulation rates, release behavior, material degradation assays, and microbial examination.
A successful drug delivery system must not only deliver the drug at the correct dose, but also to the intended target in the patient's body with proper timing to ensure maximum therapeutic efficacy. Microspheres are an attractive drug delivery system because they are made of biodegradable polymers that do not harm the body and can hold a wide variety of drugs that can be delivered to the patient with a simple injection. In addition, microspheres can ensure controlled delivery of active drug ingredients, making them an attractive procedure for biomedical scientists and healthcare professionals.
CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.