Non-Disintegrating Buccal Film Development

Non-disintegrating buccal films are pliable, thin films that are intended to be administered through the buccal mucosa, giving the medication a direct path to absorption. Because these films don't dissolve when they touch with saliva, as opposed to conventional oral formulations, the active pharmaceutical ingredient (API) is released gradually and under control. We have developed non-disintegrating buccal films, which offer a new alternative to traditional drug delivery methods and a significant breakthrough in traditional drug delivery technology.

CD Formulation has years of experience in oral thin films drug delivery services, our company utilizes advanced technology platforms and drug development expertise to provide effective non-disintegrating oral films development services. This service we offer plays an important role in the development of high-quality pharmaceutical products that meet the specific needs of our customers.

Figure 1. Preparation of oral thin films. (Özakar E, et al., 2023)

Advantages of Developing Non-Disintegrating Buccal Films

• Enhanced bioavailability. Bypassing the hepatic first-pass metabolism, buccal administration ensures higher bioavailability, maximizing the therapeutic potential of the drug.
• Improved patient compliance. The convenience of administration and the absence of disintegration contribute to improved patient compliance, particularly in populations with difficulty swallowing conventional oral dosage forms.
• Tailored therapeutic profiles. Our non-disintegrating buccal films development services enable the customization of drug release profiles, allowing for precise modulation of therapeutic effects.

Our Process of Non-Disintegrating Buccal Film Development

Formulation Design

This stage involves the selection of suitable polymers, plasticizers and active pharmaceutical ingredients (APIs) to achieve the desired buccal film properties. The solubility, stability and bioavailability of the drug also need to be considered carefully. The choice of polymer plays a key role in characterizing the mechanical and drug-release properties of the buccal membrane. The use of plasticizers in the formulation will enhance buccal film flexibility and prevent brittleness. The optimal ratio of polymer to plasticizer is critical in achieving the desired balance between mechanical strength and disintegration properties.

Development Phase

This phase involves the precise execution of the formulation design into the non-disintegrating buccal films. It is very important that the manufacturing accuracy is determined during this phase and strict quality control is implemented throughout the production process.

Pilot Stage

We focus on performance testing and safety evaluation. In this phase of performance testing, we utilize drug release kinetics, which are used to thoroughly evaluate drug release kinetics to validate the extended release profile. In addition, we utilize mechanical strength analysis to assess the mechanical strength of the film to ensure integrity during application. In the safety assessment phase, we focus on biocompatibility studies and toxicology assessments.

Manufacturing Phase

We utilize state-of-the-art technology platforms and production equipment, as well as a stringent quality control system to ensure a high degree of consistency in film thickness, drug content, and other important characteristics.

Applications of Our Non-Disintegrating Buccal Film Development

• Chronic disease management. Non-disintegrating buccal films provide an effective solution for the sustained release of medications in chronic disease management, enhancing patient compliance and therapeutic outcomes.
• Pediatrics and geriatrics. The ease of administration and controlled drug release make non-disintegrating buccal films particularly suitable for pediatric and geriatric populations, addressing the unique challenges associated with these patient groups.
• Fast-acting formulations. In situations requiring rapid drug absorption, our development services can design non-disintegrating buccal films with accelerated release profiles, ensuring prompt therapeutic effects.

Highlights of Our Non-Disintegrating Buccal Film Development Services

• Years of experience in developing novel drug delivery systems. We have a comprehensive team of laboratory technicians, all with years of drug development experience.
• Advanced technology platform. We use advanced and comprehensive drug development platforms to maximize the success rate of experiments.
• High-quality partners. We have a strict quality control system to ensure the quality of drug development.
• Customized solutions. We provide customized solutions according to the characteristics of customer projects, to maximize the satisfaction of customer project needs.

The development of non-disintegrating buccal films represents a pivotal advancement in drug delivery. CD Formulation's commitment to precision, innovation, and client satisfaction positions us as the premier choice for non-disintegrating buccal film development services. If you are interested in us, please feel free to contact us.

Reference

1. Özakar E, et al. Preparation, Characterization, and Evaluation of Cytotoxicity of Fast Dissolving Hydrogel Based Oral Thin Films Containing Pregabalin and Methylcobalamin. Gels. 2023, 9(2):147.