The cream is a semisolid emulsion containing a mixture of oil and water. Their consistency is different between liquid and solid. The development of cleansing cream and cold cream was promoted by early ointment (soothing ointment) and non irritant (soothing product) preparations, and due to the development of new technology such as emulsifier and other additives, the preparation of cream has become very easy.
Fig.1 Cream. (Lecheb F, et al. 2015)
The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of creams. CD Formulation can provide you with one-stop services to meet your needs of creams.
There are several factors to consider when preparing cream:
Oil in water emulsion is used for local application of water-soluble drugs, mainly for local effect. They do not have the greasy texture associated with oily matrix, so they are comfortable to use and easy to clean from the skin surface.
Many topical lotions contain oil as a carrier of active ingredients. It must be recognized that the type of oil used may also have an impact on the viscosity of the product and the transport of the drug to the skin. One of the most widely used oils for this type of preparation is liquid paraffin.
The choice of emulsifier used depends on its emulsifying ability, route of administration, toxicity and other factors. Most nonionic emulsifiers are less irritating and less toxic than their anionic and cationic counterparts. Some emulsifiers, such as ionic alkaline soaps, usually have a higher pH value and are therefore not suitable for use on damaged skin.
If you have a requirement about creams services, please contact us by phone or email, our colleagues will reply to you within three working days.