Buccal tablets are very small tablets that should be placed in the buccal pouch or between the gums and lips or cheek where they dissolve or disintegrate slowly and are absorbed directly. It should not be moved around with the tongue during this time, as this may make it less effective. Buccal administration can provide better bioavailability of some drugs and work faster than oral administration, because the drug does not pass through the digestive system, thus avoiding first pass metabolism.
Fig.1 A delivery of buccal administration. (Laisa Lis Fontinele de Sá, et al. 2018)
Fig.2 Anatomy of Oral Mucosa. (Kurukshetra, Haryana, 2018)
The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of buccal tablets. CD Formulation can provide you with one-stop services to meet your needs of buccal tablets.
The Advantages of Buccal Tablets
First pass -The liver is bypassed, so the bioavailability of drugs is higher.
Fast absorption-Due to the good blood supply, the absorption area is usually quite fast, especially for fat-soluble drugs.
Drug stability-the pH in the oral cavity is relatively neutral. Therefore, the drug may be more stable.
The Disadvantages of Buccal Tablets
It is inconvenient to keep the dose in the mouth. If any part of the dose is swallowed, that part must be treated as an oral dose and undergo first-pass metabolism.
Usually more suitable for small doses.
The taste of medicine may need to be masked.
The Process of Developing Buccal Tablets
Buccal tablets are produced in much the same manner as conventional tablets.
How to Contact with Us?
If you have a requirement about buccal tablets services, please contact us by phone or email, our colleagues will reply to you within three working days.
de Sá, Laisa Lis Fontinele, et al. "Design of Buccal Mucoadhesive Tablets: Understanding and Development.". Journal of Applied Pharmaceutical Science 8.02 (2018): 150-163.
Sattar, Mohammed, Ossama M. Sayed, and Majella E. Lane. "Oral Transmucosal Drug Delivery-Current Status and Future Prospects." International Journal of Pharmaceutics 471.1-2 (2014): 498-506.
Verma, Surender, et al. "An Overview on Buccal Drug Delivery System." International Journal of Pharmaceutical Sciences and Research 2.6 (2011): 1303.
Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!
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