Capsules are a solid dosage form in which the drugs and/or excipients are enclosed in a soft or hard soluble shell. Generally, drugs in capsules are powders or granules that are irritating to the esophagus and gastric mucosa that are easily volatile, easily decomposed by saliva in the mouth, easily inhaled into the trachea or have bad taste. These medicines are packed into capsules, which not only protect the medicine from being destroyed, but also protect the digestive organs and respiratory tract. Removing the capsule shell may cause drug loss, drug waste and reduced efficacy. In addition, some drugs need to be dissolved and absorbed in the intestine, and the capsule can protect the drugs from being damaged by gastric acid.
Capsule shell is usually made of gelatin or other suitable polymeric materials. According to the composition of capsule shell, capsule can be divided into hard capsules or soft capsules. In addition, capsules come in standard sizes. These sizes range from 000 to 5, which have volumes from 1.36 to 0.13 mL. The size of the 000 capsule is the highest, and 5 capsule is the smallest.
Fig.1 Diversity of capsules colors (Hoag S W, 2017)
Fig.2 Standard capsule sizes. Source: Dennis Murachanian, Capsulgel
The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the capsules. CD Formulation can provide you with one-stop services to meet your needs of capsules.
Fig.3 Hard capsules
Fig.4 Soft capsules
For capsules, the formulation requires the formation of a uniform plug of uniform weight. Relative simplicity of capsule preparation that can speed up the development process, especially for drugs with large dose and difficult to compress.
If you have a requirement about capsules services, please contact us by phone or email, our colleagues will reply to you within three working days.
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