Solid-State Characterization
CD Formulation has multiple testing instruments, including X-ray powder diffractometer, differential calorimeter scanner, laser particle size analyzer, scanning electron microscope, etc., which can provide customers with high-quality solid-state characterization services. We have extensive experience and knowledge in the field of solid-state research, and can provide in-depth analysis and professional advice on test results to help customers effectively solve problems and challenges they encounter.
Why Do Solid-State Characterization?
Drug solid-state research aims to use systematic experimental protocols and advanced solid-state characterization methods to select solid forms (such as polymorph, salt and cocrystal) with the most overall advantages (including stability, bioavailability, process development, etc.). The solid-state characterization is a necessary means to understand the nature of crystal forms and explain the formation of crystal forms, which is of great significance in the pharmaceutical industry. The comprehensive solid-state characterization is not only helpful to analyze the solid form of the drug, but also to identify the differences in physical and chemical properties between different crystal forms. Rational use of various characterization techniques to perform correct solid-state characterization of drugs and understanding the solid-state properties of drugs are qualities that pharmaceutical practitioners should possess.
What Characterization Technologies Do We Have?
| Detection technique | Method | Application |
|---|---|---|
| Crystallography | X-ray power diffraction (XRPD) Single crystal X-ray diffraction (SCXRD) Microcrystalline electron diffraction (MicroED) |
Identification of crystal forms and analysis of crystal structure. |
| Spectoscopy | Infrared Radiation (IR) Raman Teraherz (THz) Solid-state-NMR (ssNMR) X-ray photoelectron spectroscopy (XPS) |
Assisting in crystal form identification and characterization of local structures in crystals. |
| Microscopy | Electron microscope (EM) Atomic force microscope (AFM) Polarized light microscope (PLM) |
Morphological characterization of solid particles to assist in crystal form identification. |
| Thermal techniques | Differential scanning calorimetry (DSC) Thermal gravimetric analysis (TGA) Polarized light microscope (DMA) |
Characterization of thermal properties of drug solids to assist in crystal form identification. |
| Others | Particle size distribution (PSD) | Characterizing the particle size distribution of solid particles. |
| Dynamic vapor sorption (DVS) | Characterization of the adsorption capacity of drug solids for water and their stability under different humidity conditions. | |
| Karl Fischer (KF) | Accurately detecting the moisture content in samples. | |
| Brunner−Emmet−Teller (BET) | Detecting the porosity of samples. |
Advantages of Our Solid-State Characterization Services
- High-quality data: accurate analysis and interpretation by a professional team to provide reliable results and reports.
- Rapid delivery: efficient experimental processes and operational experience, delivering results in a timely manner to meet time requirements.
- Personalized solutions: provide customized solutions according to customer needs, and closely cooperate with the project.
- Price concessions, perfect after-sales service: reasonable and competitive prices, providing customers with comprehensive and professional after-sales services.
CD Formulation focuses on providing high-quality solid-state characterization services. We are committed to providing our customers with efficient and reliable solutions that meet their specific needs and create maximum value for them. For more information or interest in our services, please contact us!
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