In Vitro Efficacy Test
In vitro efficacy testing is low cost, short cycle, and through the evaluation of different products, the most suitable efficacy testing program for the product. For example, the cell biology method, first in vitro cultivation of human or animal cells, the construction of cell models, simulating the physiological environment of the human body; according to the mechanism of skin damage to select stimulants to stimulate the cells, simulating the state of skin damage, and then in contact with the sample for a certain period of time, combined with enzyme immunoassay or gene amplification, etc., to control the content of the key indicators, so as to evaluate the efficacy of the sample claimed.
In Vitro Efficacy Testing Methods
Physicochemical method is a convenient way to evaluate the efficacy of a product by testing its own physical properties and the content of specific chemical components, for example, to determine the moisturizing properties of cosmetic raw materials or products through the weightlessness method.
Biochemical method is a method to test and analyze the characteristic indexes affecting the efficacy and the content of important biomolecules, such as the scavenging of free radicals and the inhibition of tyrosinase, with the help of spectral analysis, electron microscope, and other physical and chemical technical means.
Contents of In Vitro Efficacy Testing
In vitro efficacy evaluation can realize in vitro efficacy evaluation and research of cosmetics and their raw materials by biochemical and cellular means. The laboratory is equipped with flow cytometer, various types of microscopes, enzyme markers and other instruments and equipment to realize the analysis of the material basis of cosmetics and their raw materials, high-throughput screening, and in vitro efficacy of the mechanism of research.
Teeth are not only inorganic mineral materials, but also highly optimized complex organic/inorganic biological components. Peroxide bleaching agents can cause small defects and pores on the tooth surface, destroying the organic matrix of enamel and dentin, leading to tooth sensitivity. CD Formulation provides professional in vitro cosmetic efficacy testing, including tooth whitening efficacy testing, to help customers analyze the efficacy and effectiveness of various aspects of oral care products, and provide customers with formulation development and formulation optimization.
CD Formulation can provide cosmetic skin anti-aging efficacy evaluation test, we have the qualification ability of human efficacy evaluation, and strictly comply with the requirements of cosmetic management standards.
In vitro whitening test evaluates the whitening effect of cosmetic products by controlling the skin color and melanin value of subjects before and after applying the test samples, usually in the form of semi-face control or group control, which is applicable to cosmetic products claiming to have whitening effect.
Cosmetic allergy often leads to cosmetic contact dermatitis. Cosmetic contact dermatitis refers to irritant contact dermatitis and allergic contact dermatitis caused by contact with cosmetics.
Moisturizing tests can be performed using the capacitance method, which determines the moisture content of the skin's stratum corneum at multiple points in time after a sample is applied to the skin.
CD Formulation offers in vitro anti-acne testing to help customers efficiently perform cosmetic efficacy testing, thereby facilitating the development of cosmetic products.
Among the anti-dandruff agents commonly used in cosmetics, salicylic acid is a keratinizing agent, while zinc pyrithione, pyrrolidone ethanolamine salt (OCT) and clomiprazole (CLM) are antibacterial agents.
CD Formulation can carry out soothing efficacy assessment to evaluate the safety and efficacy of the ingredients and issue professional soothing efficacy assessment reports.
Transdermal absorption of cosmetics refers to the process in which functional ingredients in cosmetics act on the skin surface or enter the epidermis or dermis according to the efficacy of the product, and accumulate and act in the region. The transdermal absorption test is widely used to evaluate the transdermal properties and toxicological effects of cosmetic ingredients.
The use of different free radical scavengers or antioxidant complexes in cosmetic products can have the effect of slowing down the aging of the skin. Most of the anti-oxidative test methods are also based on scavenging free radicals, reducing ROS levels and increasing antioxidant enzyme activities.
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