Nasal spray is used to deliver drugs locally or systemically in the nasal cavity. They are used locally for diseases such as nasal congestion and allergic rhinitis. In some cases, nasal route is more suitable for systemic therapy because it provides a good choice for injection or pill. Drugs can be absorbed very quickly and directly through the nose, many drugs exist in the form of nasal spray for systemic administration (for example, pain, migraine, osteoporosis and nausea), and other applications of nasal spray include hormone replacement therapy, Alzheimer's disease and Parkinson's disease. So nasal spray is considered a more effective way of drug delivery and can be used to cross the blood-brain barrier.
Fig.1 Spray into nostril.
The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of nasal sprays. CD Formulationcan provide you with one-stop services to meet your needs of nasal sprays.
Advantages of Nasal Sprays
Compared to oral administration, absorption in the nose can be rapid.
Greater bioavailability can be achieved.
As long acting forms of drug injected intramuscularly or implanted into the body.
Absorption into the blood happens without first undergoing enzymatic degradation in the gastrointestinal (GI) tract nor first pass metabolism in the liver, faster onset, and at a lower dose.
Systemically acting drugs could be more effective and safer when delivered intranasally directly to the blood supply within the turbinates.
Dosage form development
Formulation selection and optimization
In-vitro bioequivalence testing
Release and finished product testing
Particle sizing, droplet sizing and spray analysis
Drug and delivery assays
Structural elucidation of drug-related impurities and degradation products
Extractables and leachables studies
How to Contact Us?
If you have a requirement about nasal sprays services, please contact us by phone or email, our colleagues will reply to you within three working days.
Jason D, Samir A, Charles S, et al. Considerations for the Development of Nasal Dosage Forms[J]. AAPS Advances in the Pharmaceutical Sciences Series, 2013, 6: 99-144.
Santosh T. Formulation and Product Development of Nasal Spray: An Overview[J]. Scholars Journal of Applied Medical Sciences, 2016; 4(8D): 2976-2985.
Christian, A. Nasal Spray to the Rescue of Neurons in Stroke[J]. Molecular Therapy the Journal of the American Society of Gene Therapy, 2018, 26(10): 2333-2334.
Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!
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