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Self-emulsifying Drug Delivery System Services

About 40% of the new chemical entities show poor bioavailability due to their low water solubility. To increase the solubility of drugs, self-microemulsifying drug delivery systems (SMEDDS) are considered as an ideal technology to enhance the permeability of poorly soluble drugs in GI membranes. Self (micro)emulsifying drug delivery systems include liquid self (micro)emulsifying drug delivery systems and solid self (micro)emulsifying drug delivery systems in general. Solid self (micro)emulsifying drug delivery systems are solid formulations prepared by mixing self (micro)emulsifying components with suitable solid materials. The self (micro)emulsifying drug delivery system encapsulates the insoluble drug to form O/W type emulsion droplets with small particle size, thereby increasing the solubility of the drug; at the same time, the surfactant is also beneficial to increase the dissolution and permeability of the drug.

Schematic diagram of supersaturated self-microemulsification conveying systemFig.1 Schematic diagram of supersaturated self-microemulsification conveying system (Rosso, 2021)

Our Services

CD Formulation's self-emulsifying drug delivery system service can evaluate the bioavailability of drugs and suggest suitable product solutions. Our professional team has the ability to establish and validate analytical methods, determine oil/water partition coefficients, investigate the equilibrium solubility of drugs in water, oil, surfactants, and provide co-surfactant selection.

After the preparation of the self-emulsifying drug delivery system, the particle size after emulsification was measured and the morphology was investigated, and the stability of the emulsion after self-micro-emulsion was evaluated through in vitro dissolution experiments.

If your drug is insoluble or insoluble, please contact us, and our professional team will choose a suitable way to customize services for you to help you better develop your drug.

Advantages of Microemulsion

Microemulsion preparation can improve the solubility of water-insoluble drugs and fat-soluble drugs, promote the absorption of macromolecular drugs in vivo, and improve their bioavailability.

Enhance the stability of unstable drugs.

Small and uniform particle size, so that the inclusion of drugs to improve the dispersion, promote drug absorption through the skin.

Service Flow

First, please contact our customer service staff to inform us of your requirements.

Then, our professional team will choose a suitable way to help improve the solubility of the drug according to your requirements.

The repeatability and scientificity of the method were proved by repeated experiments.

Feedback experimental data and product plan to customer.

The Advantages of Our Services

The advantages of CD Formulation for self-emulsifying drug delivery system services

How to Contact Us?

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

  1. Rosso, A.; et al. Supersaturable self-microemulsifying delivery systems: an approach to enhance oral bioavailability of benzimidazole anticancer drugs. Drug Delivery and Translational Research. 2021, 11(2): 675-691.
  2. Banik, S.; et al. Self-emulsifying drug delivery system of (R)-α-lipoic acid to improve its stability and oral absorption. Biopharmaceutics & Drug Disposition, 2021.

Online Inquiry

Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!
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