Superoxide Dismutase (SOD)-Like Nanozyme Customization

Superoxide dismutase (SOD) is a group of metalloenzymes found in most prokaryotic cells and some eukaryotic cells and is widely present in various of organelles. SOD is expected to play an important role in the treatment of oxidative stress-related diseases as the first line of defense against ROS-mediated damage. Customized SOD-like nanozyme can solve the problems in the extraction and application of natural enzymes and have a promising application prospect.

CD Formulation is an industry leader in the customization of various types of nanozymes, and we always follow the forefront of nanozyme research to provide customized SOD-like nanozyme. Our personalized SOD-like nanozymes offer minimal cost, excellent stability, and modifiable catalytic efficiency. They have numerous uses in the industrial and biological domains.

Figure 1. Schematic illustration of metal-based nanozymes for biomedical application. (Ren X, et al., 2022)

Advantages of Customized Superoxide Dismutase (SOD)-Like Nanozyme

• High catalytic and stability. SOD-Like nanozyme has higher stability and catalytic properties, more suitable for biomedical applications.
• Multi-species enzyme activity. Our customized nanozymes have multiple different enzyme activities with high catalytic efficiency.
• Cost-effective. SOD-Like nanozyme provides a cost-effective alternative for efficient scale-up and lower manufacturing costs.

Our Process of Superoxide Dismutase (SOD)-Like Nanozyme Customization

Material Selection

We select suitable base materials such as metal nanoparticles, metal oxide nanoparticles, carbon-based nanoparticles, composite nanoparticles, etc.

Size and Morphology Optimization

Particle size and morphology greatly affect the catalytic efficiency of nanoenzymes. Through our meticulous synthesis techniques, we can precisely control the size and shape of SOD-like nanozyme to enhance the catalytic activity. In addition, we can design nanozymes with specific surface modifications to facilitate their interactions with target cells or tissues.

Characterization of Nanozyme

The size, morphology, exposed crystal surface, chemical composition, and surface modification of nanoenzymes are the key factors that determine their catalytic properties and applications. The complex interrelationship between the structure and performance of nanozymes requires us to characterize SOD-like nanozyme from three aspects: morphological analysis, compositional and structural analysis, and surface and interfacial analysis.

• The morphology analysis of nano-enzymes mainly utilizes the electron microscope observation method, such as scanning electron microscope (SEM), transmission electron microscope (TEM) to analyze and measure the morphology, size, size distribution, aggregation state of the particles.
• The composition and structure analysis of nanoenzymes mainly includes the characterization of their physical phase composition, elemental composition, crystal structure and electronic structure.
• For surface and interfacial analysis of nanoenzymes, various methods have been available, such as scanning probe microscopy, spectroscopic analysis, and thermal analysis.

Optimization of Surface Properties

To ensure the stability and compatibility of SOD-like nanozyme in biological systems, we optimize their surface properties. Our scientists can modify surface charge and hydrophobicity to minimize unwanted interactions and prevent premature degradation.

Assay

We tested the prepared SOD-like nanozyme for properties such as activity, stability, and specificity.

Applications of Our Superoxide Dismutase (SOD)-Like Nanozyme Customization Services

• Environmental remediation. The catalytic properties of SOD-like nanozymes make them valuable in environmental remediation.
• Biomedical applications. SOD-like nanozymes have great potential in various biomedical applications, where they can be used to treat diseases associated with oxidative stress, such as neurodegenerative diseases, cardiovascular diseases, and cancer.
• Industrial processes. SOD-like nanozymes have a lot of potential for usage in a variety of industrial activities, such as the development of effective and eco-friendly catalytic systems for chemical reactions.

Highlights of Our Superoxide Dismutase (SOD)-Like Nanozyme Customization Services

• Innovation services. We stay at the forefront of technological and continue to innovate our customization process, working to customize high-performance and functional SOD-like nanozymes for our customers.
• Customized services. We provide customized solutions based on each customer's specific needs, ensuring precise customization of SOD-like nanozyme for our customers.
• High-quality service. We have strict quality control measures throughout the customization process to ensure that each customized SOD-like nanozyme meets the highest standards of performance.

CD Formulation provides industry-leading customized nanozyme services. If you are interested in us, please feel free to contact us.

Reference

1. Ren X, et al. Nanozymes-recent development and biomedical applications. J Nanobiotechnology. 2022, 20(1):92.