Bleaching ingredients in whitening toothpastes are mainly peroxides. Peroxides are chemically unstable and hydrolyze to form hydrogen peroxide (H2O2), which releases reactive oxygen species to bleach colored stains. Teeth are not only inorganic mineral materials, but also highly optimized complex organic/inorganic biological components. Peroxide bleaching agents cause tiny defects and pores on the tooth surface and damage the organic matrix in enamel and dentin, leading to tooth sensitivity. CD Formulation provides professional in vitro cosmetic efficacy testing, including teeth whitening efficacy testing, to help customers analyze the efficacy and effectiveness of oral care products in all aspects, and to provide customers with formulation development and formulation optimization. CD Formulation also provides customers with formulation development and optimization services.
The main ingredients of teeth whiteners are - chemicals such as hydrogen peroxide and urea peroxide, which are strong oxidizing agents that can deconstruct the pigments stuck on the teeth into lighter shades, and the teeth will become whiter and whiter. However, when it reaches a saturation point, the whitening agent will not only not increase the whiteness of the teeth, but also do great harm to the teeth, easy to make the teeth become abnormally sensitive, triggering a variety of dental diseases.
The Lobene Pigmentation Index is a common method of evaluating tooth color based on visual inspection in clinical trials. However, its method is only suitable for evaluating the effect of removing exogenous stains from teeth, using a number from 0 to 3 to evaluate the area of the stained area and the degree of staining. Objective instruments are also very useful: for example, the image analysis instrument VISIA is utilized to make photographic records at different points in time during the same testing cycle, thus providing an auxiliary efficacy evaluation of the whitening efficacy of toothpaste.
In vitro experimental methods can also evaluate the tooth coloring properties and the whitening effect of whitening ingredients, mostly used in the pre-screening of the efficacy of the ingredients, or the efficacy of the formula to verify. For example, the thin film cleaning rate (PCR) recommended by the American Dental Association (ADA) is a very significant in vitro test for evaluating the cleaning power of a product. PCR is commonly used to evaluate the cleaning ability of toothpastes and abrasives to whiten teeth by removing exogenous discoloration through physical abrasion. The Hydroxyapatite Powder Laboratory Evaluation Method is commonly used to evaluate the stain-removing and stain-preventing ability of toothpastes and whitening efficacy ingredients, and is mainly used to whiten teeth by chemically removing or preventing exogenous tooth discoloration.
Colorimetric plates can be used to provide a semi-quantitative assessment of the effects of tooth staining. Another quantitative method involves measuring the optical reflectance spectrum in relation to different lights and intensities.
Consumers are paying more and more attention to oral health and their needs are increasing day by day, prompting the emergence of new categories of oral care products and new ingredients, as well as increasingly stringent toothpaste regulations. The efficacy of toothpaste has become the focus of attention, and efficacy evaluation is a key part of the development of good products and an important weapon. CD Formulation can test teeth whitening products in the different ways mentioned above, analyze the products in depth, and provide efficient and integrated services to our clients. If you are interested in our services, or if our company has the testing services you need, please feel free to contact us and we will provide you with the most professional services for your project.