Dendrimers are capable of encapsulating drugs through electrostatic, van der Waals and H-bonding forces or chemical bonds due to their unique properties (e.g., well-defined size, spherical shape and internal void space). The dendrimer consists of three parts: the central core of the molecule, the inner layer of the branched unit, and the outer layer of the functional group. Common types include poly-lysine (PLL), poly-propyleneimine (PPI), poly-ethyleneimine (PEI), poly-aryl ethers, and poly-amidomethylamine ( PAMAM). However, the toxicity of dendrimers is the biggest obstacle limiting their clinical applications. CD Formulation offers a more mature technology to modify dendrimers to reduce toxicity and expand their applications.
CD Formulation focuses on the development of drug transport technologies and related solutions for pharmaceutical companies or research institutions to help them accelerate their drug development process. We provide solutions for dendrimers that focus on reducing their toxicity with two main strategies: customizing biocompatible or biodegradable materials; and surface modification of dendrimers.
CD Formulation offers customizable dendrimers including polyester dendrimers and polyacetal/polyketone dendrimers.
CD Formulation typically uses polyethylene glycol (PEG) and its derivatives for surface modification. PEG and its derivatives can improve their water solubility, reduce enzymatic cleavage by metabolic enzymes and immune system in vivo, and prolong the retention time of drugs in vivo. Currently, we can successfully modify dendrimers, including bromination, amination, carboxymethylation, toluenesulfonation, methanesulfonation, aldolization, or methoxypolyethylene glycol (MPEG) chemistry. Dendrimers that are anionic or polyethylene glycolized and their derivatives are significantly less cytotoxic compared to cationic dendrimers with other surface groups. Our team of professionals will develop the right solution for you to help you accelerate drug development and drug efficacy transport.
CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.