Services List

Nanocrystal Technology for Nanocrystalline Drug Development

Nanocrystal technology is a formulation technology in which drug particles are prepared into nano-sized drug crystals by fragmentation and dispersion or precipitation crystallization, and stabilized with stabilizers. This technology is simple to prepare and has the potential for multiple routes of drug delivery and can be effectively used in novel drug delivery systems. Nanocrystalline drugs are drug particles that are directly micronized and processed to the nanoscale as a carrier-free submicron colloidal dispersion system, with particle size generally ranging from 100 to 1000 nm, containing only active ingredients and stabilizers, the role of stabilizers is to reduce the aggregation of drug crystals and improve the stability of the product.

Nanocrystal Technology for Nanocrystalline Drug Development

Advantages of Nanocrystals

  • High Safety

Nanocrystals do not use carrier delivery, so they do not contain a large amount of surfactants and carrier materials, and do not produce metabolites of materials, which is safe.

  • High Bioavailability

The micronization process reduces drug particles to the nanometer level, increases the specific surface area of insoluble drugs, improves solubility and dissolution rate, and has greater surface adhesion, prolongs the action time of drugs in the mucus layer, limits diffusion to increase the local concentration of drugs, and promotes the absorption of drugs in the gastrointestinal tract. It has also been reported that nanocrystalline drugs can saturate the efflux transport proteins on biological membranes and improve bioavailability.

  • Improve Drug-forming Properties

Nanocrystal technology is applicable to class II and IV drugs in the Biological Drug Classification System (BCS), especially the former, which greatly improves the drug-forming properties of insoluble drugs.

  • High Drug Loading Capacity

No excipients other than necessary stabilizers are needed in the product, and the drug itself is used as the delivery system with high drug loading capacity.

Nanocrystal Preparation Methods

  • Top-Down Technology
  • Bottom-Up Technology
  • Combination Method

Our Services

Nanocrystal Technology for Nanocrystalline Drug Development

CD Formulation focuses on nanocrystal technology and provides research and development support to research organizations and institutions in various disease areas. CD Formulation conducts valuable research projects in the field of drug discovery and development, using nanocrystal technology to develop new drug formulations that can further enhance drug targeting and bioavailability and improve therapeutic efficacy.

Nanocrystal Technology for Drug Development

CD Formulation offers its clients nanocrystal technology for drug development, which allows them to prepare and optimize their drugs for faster drug development, thereby facilitating the commercialization of their drugs.

Nanocrystal Drug Performance Testing

CD Formulation's performance services include testing of the drug's shape and size, as well as its biological and medical functions. Our quality control department is able to ensure the batch consistency of drug formulations to meet our clients' requirements and standards.

About CD Formulation

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

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Please note: Our products and services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!

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