Rectal Suspensions

Rectal suspensions are liquid preparations for rectal use. These suspensions are used to treat or manage localized diseases of the colon, and rectal suspensions are similar in formulation and quality to oral suspensions. Drugs administered rectally typically (depending on the drug) have a faster onset of action, higher bioavailability, shorter peak and shorter duration than those administered orally. Another advantage of rectal administration is that it tends to produce less nausea than oral administration and prevents any amount of drug from being lost through vomiting (gagging).

Our Services

CD Formulation's professional researchers can bring product solutions for rectal suspensions, providing examination and evaluation of the drug formulation before, during and after the product development, as well as giving appropriate advice to facilitate the product development and commercialization of the client. Specific services provided by CD Formulation are:

• Testing of physical and chemical properties of rectal suspensions.
• Dissolution or drug release testing.

The properties of APIs affect the dissolution rate of suspensions, such as the solubility, particle size distribution and crystal type of the API. Therefore, we also offer tests for the above, so that our researchers in pharmacology and other specialties can analyze data on various properties of rectal suspensions based on the presented data on particle size and solubility, and suggest conditions for optimization, thus facilitating the product development process. Our CD Formulations team is a leading expert in all aspects of pharmaceutical formulation development and dosage form optimization, and can design formulations for suspensions based on API properties and customer development objectives.

About the Preparation of Suspensions

The cases that need to be prepared as suspensions are:

1. When the drug is insoluble but needs to be made into a liquid formulation for clinical application.

2. When the dose of the drug exceeds the solubility and cannot be applied in the form of a solution.

3. When the solubility of the drug decreases when two solutions are mixed and a solid drug is precipitated.

4. In order to make the drug to produce slow-release effect and other conditions, can be considered to make a suspension.

Advantages of Our Services

• Experienced R&D team, complete production equipment and advanced production facilities.
• Quality, quantity and timely delivery of products with detailed characterization data.
• We will keep the content of the client's commission strictly confidential and can sign a confidentiality agreement if needed.

If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Vuong, M. T. , et al. Topiramate rectal suspensions in pediatric patients. Seizure, 2021, 85(2-3).
2. Davis, M. P. , et al. Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions. Supportive Care in Cancer, 2002, 10(2):117-138.