Growth Factor Delivery System Development

Growth factors play a crucial role in regulating a wide range of biological processes and have been recognized as powerful therapeutic agents in tissue engineering and regenerative medicine over the past decade. Due to their short half-life and potential side effects in physiological environments, their application is limited. CD Formulation is an industry leader in drug delivery system development. With our advanced drug development platforms and experienced R&D team aiming to provide high quality growth factor delivery system development services.

Figure 1. Schematics of delivering systems of growth factors based on the extracellular matrix.Figure 1. Schematics of delivering systems of growth factors based on the extracellular matrix. (Oliveira ÉR, et al. 2021)

Advantages for Developing Growth Factor Delivery System

  • More Safe. We have developed a growth factor delivery system that reduces toxic side effects and provides a higher level of safety.
  • Increase drug utilization efficiency. The application of a growth factor delivery system can reduce the number of administrations and drug dosage and increase drug utilization.
  • More stable. We select appropriate delivery vehicles to ensure the stability of the growth factor drug delivery process.

Our Process of Growth Factor Delivery System Development

Formulation Design

Our research team aims to design the best formulation to optimize the encapsulation efficiency and release kinetics of growth factors. We begin the development process by carefully selecting and formulating the optimal carrier system for the growth factor based on the drug development objective. In growth factor drug delivery system formulation design, our experienced research team will design carriers with stability, controlled release and biocompatibility.

Encapsulation Technology

We utilize advanced technologies to encapsulate growth factors in carrier systems such as hydrogel-based, nanoparticle-encapsulated delivery systems. Our these technologies ensure effective encapsulation, preservation of growth factor bioactivity, and enhancement of growth factor-specific delivery.

Characterization and Optimization

We conduct rigorous characterization analyses to evaluate the physical and chemical properties of our delivery systems and to assess their release kinetics. Through optimization studies, we refine formulations to achieve desired release profiles, stability and bioactivity.

In Vitro and In Vivo Testing

We test our growth factor delivery methods extensively both in vitro and in vivo to ensure their safety, effectiveness, and biological activity. When more advancements are needed, these investigations offer insightful analysis of the delivery systems' operation.


Once formulations are optimized and validated, we scale up the manufacturing process to ensure consistent and reliable manufacturing.

Types of Growth Factor Delivery Systems We Developed

  • Hydrogel. Hydrogels can be used to control the release of bioactive factors and cell regulatory substances in vivo. Hydrogel-based growth factor delivery systems show good prospects for clinical applications.
  • Nano delivery system. In addition to hydrogels, nano-delivery systems are also widely used in the design of new dosage forms of growth factors, such as albumin nanoparticles, polysaccharide nanoparticles, lipid nanoparticles, and synthetic polymer nanoparticles.

Applications of Our Growth Factor Delivery System Development Services

  • Bone regeneration. Growth factor delivery systems can be utilized to promote bone regeneration in cases of fractures, non-unions, and bone defects.
  • Wound healing. Chronic wounds, such as diabetic ulcers, often exhibit impaired healing due to deficient growth factor levels. Growth factor delivery systems offer a promising solution by providing sustained and localized delivery of growth factors involved in wound healing, promoting angiogenesis, fibroblast proliferation, and epithelialization.
  • Cardiovascular repair. Growth factors, such as vascular endothelial growth factor (VEGF), have shown potential in promoting angiogenesis and cardiac tissue regeneration.

Highlights of Our Growth Factor Delivery System Development Services

  • Expertise and experience. With years of experience in drug delivery system development, our research team has in-depth knowledge and expertise in growth factor delivery system development.
  • Customization and collaboration. We develop customized development services based on the needs of our client's projects to ensure that the final product meets their vision and requirements.
  • Advanced development platform. With our state-of-the-art facilities and cutting-edge technology, we are capable of handling projects of varying complexity and size.

CD Formulation is at the forefront of growth factor delivery system development. Our extensive experience and expertise in the field have enabled us to perfect a comprehensive and efficient development process. If you are interested, please feel free to contact us.


  1. Oliveira ÉR, et al. Advances in Growth Factor Delivery for Bone Tissue Engineering. Int J Mol Sci. 2021, 22(2):903.
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