Tablets

Tablets are the solid dosage form containing active substances and excipients, usually circular in shape and may be flat or biconvex. They are prepared by the compression method and are hence called the “Compressed Tablets”. Tablets are the most popular dosage form in use today, about two-thirds of all prescriptions are dispensed as solid dosage forms, and half of these are compressed tablets. They are usually taken orally, but also can be administered sublingually, buccally, rectally or intravaginally. Tablets can be divided into conventional tablets, coated tablets (sugarcoated tablets, filmcoated tablets, entericcoated tablets), multilayer tablets, effervescent tablets, chewable tablets, dispersion tablets, sublingual tablets, buccal tablets, implanted tablets, solution tablets, slow release tablets.

The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, so CD Formulation can provide you with various options for the tablets to fit your needs. In addition, we can also provide you with customized services.

We Can Provide You with The Following Services:

Formulation Technologies

• Wet granulation
• Dry granulation
• Hot melt extrusion
• Granule lubrication

Manufacture of the Tablets

The tablets manufacturing process usually can be classified as granulation and direct compression.

In the tablet pressing process, all the ingredients should be well-mixed. If a sufficiently homogenous mix of the components cannot be obtained with simple blending processes, the ingredients must be granulated prior to compression to assure an even distribution of the active compound in the final tablet. Two basic techniques are used to granulate powders for compression into a tablet: wet granulation and dry granulation. Powders that can be mixed well do not require granulation and can be compressed into tablets through direct compression.

Fig.1 Schematic diagram of dry granulation and two different techniques. Method I is roller compaction and Method II is slugging (Shanmugam S. 2015).

Fig.2 Schematic diagram of conventional wet granulation (Shanmugam S. 2015).

If you have a requirement about ointments services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Sharma D, Godbole M D, Lanjewar A, et al. Formulation and Evaluation of Tablets Containing Poorly Water Soluble Drug by MADG Method[J]. 2017.
2. Serajuddin A T M. Solid Dispersion of Poorly Water‐Soluble Drugs: Early Promises, Subsequent Problems, and Recent Breakthroughs[J]. Journal of Pharmaceutical Sciences, 1999, 88(10): 1058-1066.
3. Li D X, Oh Y K, Lim S J, et al. Novel Gelatin Microcapsule with Bioavailability Enhancement of Ibuprofen Using Spray-Drying Technique[J]. International Journal of Pharmaceutics, 2008, 355(1-2): 277-284.
4. Josef S S B S S, Khinast L J G. Gluing Pills Technology for the Production of Multi-Layer Tablets[J]. 2017.