Mesoporous Silica Nanoparticles Drug Delivery Services

Mesoporous silica nanoparticles (MSNs) are a novel nanostructured drug delivery system. Monodisperse silica microspheres have pore sizes ranging from 2 to 50 nm, making them ideal for a variety of biological applications. They have unique properties such as tunable surface area, good surface characteristics and the ability to improve pharmacokinetic properties of drugs. In addition, the large number of pores allows drug incorporation and transport of drugs to various sites, making monodisperse silica microspheres a viable platform for oral drug delivery.

Fig.1 Types of mesoporous silica nanoparticles. (Sreeharsha et al., 2022)

Mesoporous Silica Nanoparticles Offer the Following Advantages:

• Controllable mesoporous structure and size-adjustable pore size distribution facilitate controlled drug loading and drug release.
• High specific surface area and pore capacity providing the possibility of drug adsorption and thus loading into the pore channels of the particles.
• Satisfactory results in in vivo biosafety assessment in terms of cytotoxicity, biodegradation, in vivo distribution and excretion.
• The easily functionalized surface is more suitable for controlled drug release and targeted drug delivery, thus improving the therapeutic effect of drugs and reducing the toxic side effects of anticancer drugs on normal cells.

Our Services

CD Formulation offers mesoporous silica nanoparticle drug delivery services for the adsorption and delivery of proteins, enzymes, antibodies and nucleic acids, etc. We are proud to offer our customers customization and functionalization services for silica nanoparticles to help them better develop their drugs.

Customization Services for Silica Nanoparticles

CD Formulation offers customization services for silica-based oral drug delivery systems including non-porous silica nanoparticles, mesoporous silica nanoparticles, hybridized silica nanoparticles and diatomic silica nanoparticles.

Functionalization of Mesoporous Silica Nanoparticles

CD Formulation allows functionalized modification of mesoporous silica nanoparticles by assembling functional substances into the mesoporous pore channels of the particles. The surface of mesoporous silica nanoparticles is rich in silica hydroxyl group, and the added silica hydroxyl group is easy to interact with other organic functional groups, so that the organic functional groups are grafted to the pore wall of the particles through covalent bonding. Our professional researchers can introduce functional groups such as amino groups, alkyl groups, sulfhydryl groups, carboxylic acids, thiols and transition metal complexes into mesoporous pore channels in the pores.

Applications of Mesoporous Silica Nanoparticles

• Cancer Therapy
• MSNs in Cell Imaging and Photosensitizer Carrier
• MSNPs in Vaccine Delivery
• MSNPs in Gene Delivery

About CD Formulation

CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.

Reference

1. Sreeharsha, Nagaraja, et al. Multifunctional Mesoporous Silica Nanoparticles for Oral Drug Delivery[J]. Coatings, 2022, 12(3): 358.