Suppositories is a solid dosage form, which is generally consists of an active ingredient loaded into an inert base and has a certain shape for cavity administration. Suppositories is a solid at room temperature, but when it is inserted into the cavity of human body, it will dissolve or melt and exert local or systemic effects. Suppositories can be divided into different types according to the different cavity used, such as anal suppository, vaginal suppository, urethral suppository, laryngeal suppository, ear suppository and nose suppository. At present, rectal suppository and vaginal suppository are commonly used.
Fig.1 Glycerin suppositories (Wikipedia).
The team of CD Formulation is leading experts in all aspects of pharmaceutical formulation development and dosage form optimization, we can accord the characteristics of the API and the development goals of the customers to design the formulation of suppositories. CD Formulation can provide you with one-stop services to meet your needs of suppositories.
Compared with oral dosage form, suppositories have a higher bioavailability and faster onset. Due to its unique advantages, suppositories as an alternate form of oral medication in the following situations:
The preparation of suppositories can be divided into three types: fusion moulding, compression moulding and hands moulding. Genelly, hands moulding is used only in the pharmacy, and fusion methods can be used for all types of suppositories. This method first melts the suppository matrix, then disperses or dissolves the drug in the melted matrix, then pour the mixture into the suppository mold, and after the mixture coagulates, the suppository is removed from the mold.
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