Dioxane (1,4-dioxane, CAS No. 123-91-1, molecular formula C4H8O2) is a colorless, transparent, volatile liquid at room temperature. It can be used in water sources and foods (such as: tomatoes). There are traces in shrimp, coffee, and it is often used as a solvent in the production of paints, pesticides, medicines and other products. It has been assessed by IARC (International Agency for Research on Cancer) as a possible carcinogenic risk to the human body, and is also a banned component of cosmetics. Since dioxane is a by-product in the preparation process of common cosmetic raw materials such as polyethylene glycol and its esters, poly(ethoxylated) ethers, mixed polyethers, and ethoxylates, it will be technically inevitable. The reason is that it is brought into the product with the raw materials, so it is one of the safety risk substances of high concern in the cosmetics industry.
1,4-dioxane is used as a stabilizer for chlorinated solvents such as trichloroethane and trichloroethylene. 1,4-dioxane is in many different products like cosmetics, shampoos, baby soaps, deodorants, cosmetics, personal care products and shampoos. It is also in dyes, greases, varnishes, paint strippers, waxes, food additives and pesticides. 1,4-dioxane is used as a solvent. Acute (short-term) inhalation exposure to high levels of 1,4-dioxane has caused vertigo, drowsiness, headache, anorexia and irritation of the eyes, nose, throat, and lungs in humans. It may also irritate the skin.
Common ingredients with dioxane risk are: Sodium Laureth Sulfate, Sodium Cocoeth Sulfate, Ammonium Laureth Sulfate, Laureth, Cocoeth, Oleth, stearyl alcohol polyether, polysorbate, lanolin alcohol polyether, PEG-120 methyl glucose dioleate, etc.
United States: The California 65 standard requires that the dioxane content in products exceeding 10 ppm must be labeled.
European Union: EU Consumer Safety Science Committee (SCCS) recommends less than 10 ppm as a safe level.
Australia: According to the official website of the Australian Health Service, the technical documents and recommended standards for the evaluation of dioxane suggest that, except for food and pharmaceuticals, the ideal limit of dioxane in daily consumer products is 30ppm. When the content does not exceed 100 ppm, it is acceptable in terms of toxicity.
China: The residual concentration of dioxane in cosmetic products should meet the requirements of the "Safety and Technical Specifications for Cosmetics". "Limits of Hazardous Substances in Cosmetics", that is, the residual concentration of dioxane should be less than 30 mg/kg.
The method that ATS uses to perform 1,4-dioxane testing is called Gas-Chromatography / Mass-Spectroscopy (GC-MS). This test can detect compounds of interest in the sample's chemical makeup and measure them at a parts-per-million (ppm) detection limit.
After the samples were heated and extracted in the headspace vial, they were determined by gas chromatography-mass spectrometry, qualitatively by using the relative abundance ratio of ions, measured by the selected ion monitoring mode, and calculated by the standard curve method.
CD Formulation can provide you 1,4-dioxane test in cosmetics. At the same time, it will continue to pay attention to the progress of the safety of dioxane residues in cosmetics, track the regulatory requirements for residue limits in relevant countries and regions, and pay close attention to the safety of cosmetics. Effectively protect the health of consumers and promote the healthy development of the industry.
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