Conventional nanoemulsions are mainly prepared from nonionic or anionic emulsifiers combined with suitable oil phases, which usually have a negative surface charge, and cationic nanoemulsions can be formed by adding positive charge inducers such as oleylamine, chitosan and stearylamine to them. Cationic nanoemulsions are often used to improve the solubility and permeability of insoluble drugs, and can also combine with large molecules such as nucleic acids and proteins (which contain a large number of negatively charged functional groups) to form complexes that protect them from enzymatic degradation and promote their absorption.
Fig.1 Schematic of cationic nanoemulsion. (Bruxel et al., 2011)
CD Formulation can design cationic nanoemulsions with different functions and optimize them according to customers' needs. Among them, formulation optimization service means preparing nanoemulsions with different ratios of raw materials (oil, non-ionic or ionic surfactants, penetrants, phospholipids, etc.), evaluating the performance of the prepared nanoemulsions after autoclaving, and screening the product formulation with the best results.
CD Formulation has professional instruments and laboratories to perform particle size analysis, zeta potential measurement and morphology tests on cationic nanoemulsions.
CD Formulation provides services that drive innovative and impactful solutions and insights to meet the toughest challenges. We offer an integrated, full-service approach to help our clients better develop and transport drugs for effectiveness.
Cationic nanoemulsions are well suited as carriers for oral drug delivery, and they can more significantly facilitate transmembrane drug transport with significantly lower TEER values than conventional nanoemulsions.
The nanoemulsion as an ophthalmic drug carrier can prolong the retention time and contact time with the cornea, increase the corneal permeability of the drug, and improve the bioavailability of the drug.
There are negatively charged protein residues in the cell membrane of epithelial cells, and the drug delivery system with positive surface charge can be electrostatically adsorbed with the cells to increase the drug permeability and prolong the drug action time, so all epithelial cells are selective to the drug delivery system with positive surface charge.
CD Formulation provides integrated innovation solutions from strategy to implementation to help you increase opportunities and address challenges. Through our in-depth experience in many different industries, including consumer and technology, we bring innovative solutions and cross-industry best practices to drug development. If you have a requirement about our services, please contact us by phone or email, our colleagues will reply to you within three working days.