Methanol is used in cosmetic formulations mainly as a vehicle or solvent. It has a simple chemical structure, so it can easily dissolve many other ingredients in itself. Another use of methanol is as a denaturant. It typically find it used in denature ethyl alcohol common in many cosmetic products. Ethanol can be used as a solvent, defoamer in cosmetics, and the main reason for methanol exceeding the standard is caused by its raw material ethanol. Methanol has a strong stimulating effect on the respiratory tract and mucous membrane, and can be absorbed through the respiratory tract and skin. It is a restricted toxic substance in cosmetics. Therefore, methanol residues in cosmetics are increasingly valued by consumers.
Studies in recent years have shown that methanol inhibits some oxidative alcohol systems in the body, inhibits the aerobic decomposition of sugar, causes the accumulation of lactic acid and other organic acids, and causes acidosis. Methanol mainly acts on the central nervous system, has obvious remote anesthesia effect, can cause cerebral edema, has a special selective effect on optic nerve and retina, causes optic atrophy, and leads to blindness in both eyes.
The skin absorption of methanol was studied by monkeys and others, and it is speculated that it is dangerous for humans to absorb 30 mL of methanol. Acute toxicity:
LD50 (oral) human: 1400 mg/kg
LD50 (inhalation) human: 4000 mL/L.
Because methanol is highly toxic, the content of methanol in cosmetics should be strictly controlled.
Currently, the standard test method for methanol in cosmetics is distillation gas chromatography. In addition, solid-phase micro-extraction-gas chromatography, head-space gas chromatography, and colorimetry can also detect methanol.
The gas chromatography for methanol test method in cosmetics is as follows.
After gas-liquid equilibrium, direct extraction or distillation, the sample is separated by gas chromatography, detected by hydrogen flame ionization detector, qualitative according to the retention time, quantitative by peak area, and calculated by the standard curve method.
CD Formulation can provide you with testing services for methanol in cosmetics, and further evaluate the safety of cosmetics by testing the content of methanol in cosmetics. Whether you are a manufacturer, distributor or consumer, we have a professional methanol testing service team to complete your methanol test report in the quickest way possible.
CD Formulation can provide comprehensive professional, impartial and high-quality cosmetic testing services, and is committed to providing meaningful and influential testing services for hazardous substances in cosmetics.
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