Customized Services for Dry Emulsion

Dry emulsions consist of a matrix containing a water-soluble or water-dispersible polymer dispersed in a hydrophobic phase. Dry emulsions are of interest because of their stability and slow release effect. Dry emulsions are a potential oral delivery system for lipophilic and low soluble APIs as well as for APIs requiring protection against light or oxidation. Based on our extensive experience in drug delivery systems and professional technical support, we can bring you high quality products and services.

Fig. 1 Dry emulsion products: a) spray dried dry emulsion powder; b) dry emulsion layered pellets. (Pohlen et al., 2022)

Features of Dry Emulsions

• They improve the bioavailability of the drug.
• Dry emulsions are attractive because they are physically and microbiologically stable formulations.
• They represent a potential oral delivery system for lipophilic and low solubility drugs.
• For drug substances that need to be protected from light or oxidation.
• Dry Emulsions provide the most stable effective blood levels over prolonged treatment.

Dry Emulsion Customization Services

CD Formulation offers custom dry emulsion services, including dry emulsion synthesis, drug dry emulsion preparation, dry emulsion physicochemical property analysis, drug content determination, in vitro dissolution testing, and more, providing a full range of services exclusive to you and a solution for your project.

Dry Emulsion Characterization

• Droplet size and surface charge analysis

Droplet size and zeta potential of emulsions are measured by laser particle analyzers.

• Rheology analysis

Rheological measurements are performed using a rheometer. Using a concentric cylinder geometry, 20 mL of each sample was placed into the inner cylinder and equilibrated for 2 minutes prior to measurement. Viscosity tests were performed at 25°C over a range of shear rates from 0-300 s^-1.

• Laser scanning confocal microscopy observation

Confocal laser scanning microscopy was used for the visualization of powder particles. Spray-dried and freeze-dried powder particles were placed on glass slides and labeled with a mixture of Fast Green and Nile Red. The dye mixture was dissolved in polyethylene glycol in a ratio that allowed the dye molecules to diffuse into the pellets without affecting the morphology of the pellets and prevented dissolution. Confocal images of each system were taken using an oil immersion objective to generate a three-dimensional structure of the particles and to identify surface lipid staining.

• Scanning electron microscopy testing

Spray-dried and freeze-dried emulsion powders were attached to a double-sided adhesive carbon sheet mounted on a scanning electron microscope mount and then coated with chromium. Scanning electron microscopy images were collected using field emission electron microscopy.

• Drug content analysis

Dry emulsions were weighed and dissolved in a suitable solvent. The stock solution was filtered through filter paper and diluted appropriately. The drug content was analyzed by UV spectrophotometer.

• Moisture content analysis

Moisture content is determined by thermogravimetric analysis. Moisture content can be determined on the basis of weight loss between 50 ~ 1200°C.

• In vitro dissolution studies

The dissolution of pure drug, dry emulsions, dry suspensions and tablets were compared according to the time required for maximum drug release. The cumulative percentage release of drug was observed at different times.

• Statistical analysis

All the experiments were repeated at least three times. One-way ANOVA was used to compare the means of the data.

Application of Dry Emulsions

• Oral administration
• Transdermal administration
• Cosmetic formulation

If you are interested in our services, or if you need a service that is not listed, please feel free to contact us and our experts will provide you with the best quality service.

Reference

1. Pohlen, M., et al. (2022). Relative bioavailability enhancement of simvastatin via dry emulsion systems: Comparison of spray drying and fluid bed layering technology. European Journal of Pharmaceutics and Biopharmaceutics, 172, 228-239.