The some chemical substances contained in cosmetics can cause serious harm to human health, especially some manufacturers have added prohibited and restricted substances in cosmetics. For example, adding antibiotics to cosmetics, the antibiotics commonly added in cosmetics mainly include chloramphenicol, metronidazole, tetracycline, quinolones, imidazoles, etc. Especially in anti-acne cosmetics, some manufacturers illegally add various antibiotics in pursuit of short-term efficacy of products. Long-term use will induce flora imbalance, cause contact dermatitis, and even lead to serious internal organ damage, which is life-threatening.
When detecting antibiotics in cosmetics, the first problem we face is to separate the antibiotics. The form of cosmetics can be divided into solid and liquid. Usually, cosmetics with liquid matrix are easy to conduct sample processing, and the recovery rate is also good. However, because the volume of cosmetics such as facial cleanser and gel matrix is not easy to be fixed, and these products usually have too many surfactants, it will lead to backward transfer of the retention time of the sample to the added standard substance in the sample recovery test, affecting the accuracy of the test. In this case, we need to remove the mechanical interference in cosmetics, maintain a constant retention time and high recovery rate.
CD Formulation, as a professional one-stop solution for cosmetics provider, offers a series of cosmetics one-stop testing services, including the microbial contamination test, hazardous substance test, analysis of restricted substances, preservative test and antibiotics test, which help customers to know enough specific information about cosmetics for better cosmetics development and make sure the cosmetics are safe.
CD Formulation provides a variety of testing services and complete test reports based on decades of industry experience. From initial research including pretreatment of samples, stationary phase selection, mobile phase selection and establishment of detection methods, etc. We work closely with customers to produce methods which meet or exceed their detection needs. According to your sample type and sample quantity, we choose the appropriate sample handling method and testing equipment, our professional team can quickly accurately provide you with the final test report. We used liquid chromatography-triple quadrupole mass spectrometry ( LC - MS / MS ) to separate and identify the samples, which can quickly, efficiently and accurately detect the content of multiple antibiotics. In addition, we can also use high performance liquid chromatography (HPLC) or ultra high performance liquid chromatography (UPLC) for the determination of antibiotics in cosmetics to meet your different needs.
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