Suspending agent is a kind of viscous hydrophilic colloidal substance, which can increase the viscosity of the dispersion medium to slow down the sedimentation speed of particles, and adsorb on the surface of the particles to become a barrier to prevent the aggregation and agglomeration of particles. It acts as a suspending agent in the flocculation system. Especially important, suspending agents with thixotropy are ideal suspending agents. But it should be noted that the amount of suspending agent should be appropriate. Adding too much suspending agent will make the system too viscous and not suitable for dumping; after taking it, the residual time in the oral cavity is prolonged and the aftertaste is not good, and the particles are not easy to redisperse after they have settled. In addition, attention should be paid to the drugs in the suspending agent and the suspension or their curative effect; when the suspending agent and the drug are oppositely charged, the charge is neutralized or the system contains a large electrolyte due to colloidal coalescence due to salting out, so it is designed when choosing a suspending agent in the formulation, careful consideration should be given to the trial production of small samples, and it is best to be supplemented by rheological parameter determination in order to select the best variety. CD Formulation provides various excipient molecules for customers. Our pharmacy or other professional researchers and experimenters are constantly developing new product solutions. We can customize suspending Agents and provide solutions for drug development and research.
Molecular Suspending Agents
Generally, glycerin, syrup, sorbitol, etc. are low molecular weight suspending agents. The most commonly used is glycerin. Glycerin is a colorless or slightly yellow transparent viscous liquid, non-toxic, odorless, non-corrosive, and has strong hygroscopicity. It can react with inorganic and organic acids to form a variety of esters. It can be used under certain conditions.
Polymer Suspending Agents
Polymeric suspending agents include gums such as acacia, rose gum, etc.
Silicic Acid Suspending Agents
Generally diatomite colloid, magnesium aluminum silicate colloid, silicon dioxide, aluminum silicate, silica bentonite, etc. are silicic acid suspending agents. Such suspending agents are less reported than polymer suspensions.
The choice of suspending agents should be based on the nature of the drug in the suspension, because the suspending agent may interact with the drug or other ingredients in the suspension. For example, some suspending agents can be combined with certain drugs to make the drug can not or delay the effect; if the suspending agent and the drug are charged oppositely, the charge is neutralized or the system contains a larger amount of electrolyte due to "salting out" and colloidal coalescence occurs. Therefore, careful consideration should be given to the selection of suspending agents in the design of prescriptions, through trial production of small samples, and preferably with the measurement of rheological parameters in order to select the best varieties.
If you have any requirements for excipients, please contact us by phone or email, and our colleagues will reply to you within 2-4 working days.