Binder Excipients

CD Formulation has professional production facilities and management experience, as well as professional staff with extensive expertise. We can provide binder excipients with different specifications and quality requirements, and customize the production of corresponding products according to customer needs.

Background of Binder Excipients

The role of the binder excipient is to act as a binder to bind powder, granules and other dry ingredients together to give the product the necessary mechanical strength. They can also give low-dose pills. Usually used for wet granulation, adding a binder to create more effective and predictable particle formation. These excipients can agglomerate powders into granules in a process called granulation, and also affect their properties, such as compaction, drug release, flow, solubility, and strength. Binder excipients are used in the process of drug or drug preparation to improve the disintegration, volume, bioavailability and dissolution of the drug.

Classification

Binder excipients hold the ingredients of the formulation together, for example in a tablet. The binder ensures that tablets, powders, granules and others can be formed into the required mechanical strength. In addition, they give low active dose tablet volume.

Binders are usually classified as follows:

• Microcrystalline cellulose
• Starch
• Lactose
• Sugar alcohols
• Polymers like PVP and PEG
• Isomalt

Application

• Capsules, chewable tablets, direct compression, rolling, sustained release.
• Thickener, suspension stabilizer, reduce precipitation, inhibit crystallization.
• For non-erosive matrices using direct compression, controlled release matrices. Matrix forming agent in transdermal patches and external films.
• The dry binder in tablets, capsules and granules is used as a film-forming agent in tablet coatings and coatings, and as a film-forming agent in topical sprays. It is widely used in HME process.

Limiting Factors in the Selection of Adhesive Excipients

1. Adhesives and solvent of adhesives are considered for drugs with heat and humidity instability. Choose anhydrous, low drying temperature adhesive and its solvent.

2. Related to mixing time: the longer the mixing time in the system of soft material, the greater the viscosity of soft material, the harder the particles produced.

3. When the amount of auxiliary materials in the prescription accounts for more than 80%, on the premise of not affecting the nature of the main drug, should focus on the characteristics of the auxiliary materials to choose the adhesive. If the use of sucrose as an auxiliary material, its dosage reaches more than 80%, it is necessary to take into account the characteristics of "sucrose in water viscidity becomes stronger", choose non-water solvent to dissolve the adhesive (only soluble in water but not soluble in organic solvent adhesive is not applicable), reduce the viscosity between particles, relatively enhance the viscosity inside the particles.

4. Different solvents and different concentrations of adhesives have different viscosity and granulation effects.

CD Formulation is a leading manufacturer of excipients that help improve the performance of pharmaceuticals and other products in the pharmaceutical industry. We develop, manufacture and market pharmaceutical excipients in solid, semi-solid and liquid dosage forms. If you have any requirements on binder excipients, please do not hesitate to contact us by phone or email in time, our colleagues will reply to you within 2-4 working days.