Liposome is an artificial membrane. Its appearance is a small sac. Liposome is a single-layer or multi-layer sac-like globule composed of phospholipids and cholesterol. Phospholipids are an important substance among them, which play a role as a skeleton. Cholesterol is a molecule interspersed in phospholipids to adjust the fluidity of liposomes. The phospholipid molecule is composed of two parts, one is the hydrophilic part, which is composed of a phosphoric acid group and an ammonia-containing base; the other is the lipophilic part, which is composed of two very long hydrocarbon-based chains. Liposome is a targeted drug carrier, which belongs to a new dosage form of targeted drug delivery system. It is first swallowed by the reticuloendothelial system, which then activates the collective autoimmune function, and brings the self-encapsulated drugs into specific parts of the body, mainly in tissues and organs such as the liver, spleen, lung, and bone marrow. Liposomes have little toxic and side effects on the body, and their lipid bilayers and biological membranes have greater similarity and tissue compatibility. The drug delivery method of liposomes is easy to be absorbed by the tissues. This drug delivery method improves the efficacy of the drug. Reduce the amount of medicine and improve safety. Reduce toxic and side effects, so it has become a hot spot in the research of pharmaceutical preparations.
The fats or fatty acids used in the production of auxiliary materials are strictly derived from plant raw materials. Common lipid auxiliary materials are esterified products obtained by esterification of fatty acids and alcohols (such as glycerol polyethylene glycol, propylene glycol or polyglycerol), or vegetable oils. Fatty alcoholysis products are esterified with glycerol, polyethylene glycol, and propylene glycol. According to the degree of esterification of different types of fatty acids of different lengths and the size and nature of the amphoteric group, the lipid excipients we provide can solve Various problems encountered in prescription research, such as solubility, permeability and regulation of drug release behavior.
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Lipid excipients can deal with most of the thorny problems encountered in drug development, such as improving drug solubility and bioavailability; changing drug release behavior for better therapeutic effects; and improving patient compliance Taste masking treatment, etc. At the same time, lipid excipients can also deal with the stability problems of sensitive active drugs and the lubrication problems in the actual production process.
The specific applications are:
Fig.1 Application of Lipid Excipients
CD Formulation provides a series of functional lipid excipients and corresponding lipid technology to increase the solubility of poorly soluble drugs and improve the bioavailability. Used as a co-surfactant in type II and type III lipid formulations. Used as a solubilizer and co-surfactant in the external microemulsion formulation. If you have any requirements for excipients, please contact us by phone or email, and our colleagues will reply to you within 2-4 working days.