Surfactant is a common functional drug excipient, which can change the contact Angle between liquid and tablet by reducing interfacial tension, so as to improve the hygroscopicity of tablet. The contact Angle between water and tablets is closely related to disintegration, dissolution and absorption of tablets. CD Formulation offers surfactant excibients, and we have pharmacy-related researchers and laboratory staff, as well as professional laboratory equipment, to provide product purity and properties to meet your requirements. In addition to bringing you products, we also provide custom surfactant excipients and product solutions to help you solve the problems encountered in the drug development process.
Surfactants increase drug solubility. The surfactant improves the wettability of the drug, thereby increasing the permeability of the dissolution medium in the solid drug particles. Surfactants are mainly divided into the following three types:
Anionic surfactants are a class of surfactants. After dissociating in water, hydrophobic anions are formed. For example, the fatty alcohol sodium sulfate is surrounded by water molecules, that is, it dissociates into two parts, ROSO2-O- and Na+. The negatively charged ROSO2-O- has surface activity. Anionic surfactants are divided into four categories: carboxylate, sulfate, sulfonate and phosphate, and have good decontamination, foaming, dispersion, emulsification, wetting and other characteristics.
Non-ionic surfactants have good hard water resistance and low foaming characteristics, so they are suitable for special detergents. Because of its multiple properties of dispersing, emulsifying, foaming, wetting, and solubilizing, non-ionic surfactants are classified according to hydrophilic groups, including polyoxyethylene and polyol.
Cationic surfactants have good bactericidal, algae-killing and anti-mildew abilities, and have a wide antibacterial spectrum, low dosage, low irritation, low mildew, no peculiar smell, and less pollution, so they are widely used. Cationic surfactants have a positive charge, which is opposite to that of anionic surfactants. The combination of the two will generally cause precipitation and loss of surface activity. It can be used in conjunction with non-ionic surfactants. The consumption of cationic and zwitterionic surfactants and other amine derivatives is only about 10% of the total amount of synthetic surfactants, but its value accounts for about 25%. Because of its relatively high price, it is not necessary for cationic surfactants. In systems with special properties, other surfactants are generally used.
Surfactants have a variety of roles in pharmaceutical formulations.
CD Formulation is a leading manufacturer of excipients, serving the pharmaceutical industry to help it improve the performance of its products. We develop, produce and sell pharmaceutical excipients for solid, semi-solid and liquid dosage forms. If you have any requirements for excipients, please contact us by phone or email, and our colleagues will reply to you within 2-4 working days.