Hydrotropic agent excipients is a substance added to a mixture of two or more separate substances that are usually incompatible so they can be mixed. Hydrotropic agent excipients is added to increase the solvent capacity of the main substances in the mixture. CD Formulation provides customers with various excipient molecules. Our pharmacies or other professional researchers and experimenters are constantly developing new product solutions. We can custom hydrotropic agent excipients for customers, and can also provide customers with solutions for drug development and research.
Hydrotropic agents refer to the third substance that can form soluble intermolecular complexes, associations or double salts with poorly soluble drugs in the solvent. Hydrotropic agents are soluble in water and are mostly low-molecular compounds, which can increase the solubility of the drug several times or even dozens of times after forming a complex with the drug. The main difference is that the third substance added is a low-molecular compound, rather than a colloidal electrolyte or a non-ionic surfactant.
Increasing the solubility of poorly soluble drugs is beneficial to the preparation and application of preparations.
Commonly used hydrotropic agents can be divided into two categories: one is certain organic acids and their salts, such as sodium benzoate, sodium salicylate, p-aminobenzoic acid, etc. These are hydrotropic agents that are more commonly used in preparations; the other is amides compounds such as urethane, urea, acetamide and so on. But many other drugs also have better solubilizing effects.
1. Organic Acids
Sodium benzoate, also known as sodium benzoate. It is usually used for the antiseptic and anti-mildew of oral liquid medicines, especially the neutral or slightly alkaline medicines that are not suitable for preserving with benzoic acid and the antiseptic of food. This product is white granular, powder or crystalline powder; it is odorless or has a slight benzoin smell, and the taste is slightly sweet and salty. Easily soluble in water, slightly soluble in ethanol.
2. Amide Compounds
3. Other Hydrotropic Agents
CD Formulation is a leading manufacturer of excipients, serving the pharmaceutical industry to help it improve the performance of its products. The company's employees are composed of people who have been engaged in research, production and application of excipients for many years. We develop, produce and sell pharmaceutical excipients for solid, semi-solid and liquid dosage forms. If you have any requirements for excipients, please contact us by phone or email, and our colleagues will reply to you within 2-4 working days.