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Methionine
Product Details
Category
Flavoring agent
Molecular Formula
C5H11NO2S
Molecular Weight
149.21
Grade
Pharmceutical Excipients
Description
Methionine occurs as a white or almost white, crystalline powder or colorless crystals.
UNII
AE28F7PNPL
Chemical Name
(2S)-2-Amino-4-methylsulfanylbutanoic acid
CAS Number
63-68-3
Synonyms
α-Amino-g-methylmercaptobutyric acid; (S)-2-amino-4- (methylthio)butanoic acid; 2-amino-4-(methylthio)butyric acid; L - methionine; methioninum; g-methylthio-a-aminobutyric acid.
Administration route
Oral; Injection
Dosage Form
Oral tablets; Injection solutions; powders for reconstitution
Stability and Storage Conditions
Methionine is sensitive to light and should be stored in a cool, dark place.
Source and Preparation
Numerous methods have been described for manufacture of methionine, including hydrolysis of methionine amide and 5-(methylmercaptoethyl)-hydantoin.
Applications
Methionine is used in oral pharmaceutical formulations as a flavoring agent. It has been included in parenteral formulations as a pH controlling agent, and it has also been used experimentally as an antioxidant with antibodies. Methionine is also used therapeutically in oral tablets.
Safety
Methionine is used in oral pharmaceutical formulations. The pure form of methionine is mildly toxic by ingestion and by the IP route.
LD50 (rat, IP): 4.328 g/kg
LD50 (rat, oral): 36 g/kg
LD50 (rat, IP): 4.328 g/kg
LD50 (rat, oral): 36 g/kg
Incompatibilities
Methionine is incompatible with strong oxidizing agents.
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